A5003460749- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Assisted Reproductive Technology and Twin Pregnancy
- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- Prenatal Screening and Diagnostics
- Retinal Diseases and Treatments
- Healthcare and Environmental Waste Management
- Cellular Mechanics and Interactions
- Infectious Encephalopathies and Encephalitis
- Alzheimer's disease research and treatments
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Cytomegalovirus and herpesvirus research
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Cancer Cells and Metastasis
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Enzyme Structure and Function
- Sustainable Supply Chain Management
- Renal and related cancers
- 3D Printing in Biomedical Research
- Protein Degradation and Inhibitors
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Jiangxi Maternal and Child Health Hospital
2024-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024-2025
Shanxi Medical University
2025
Xi’an University of Posts and Telecommunications
2024
Guiyang Medical University
2023-2024
Qihe People's Hospital
2011
Background The role of sperm DNA fragmentation index (DFI) in fertility remains controversial. Herein, we analyzed its association with semen parameters, embryonic development, and pregnancy outcomes after vitro fertilization (IVF) treatment. Additionally, assessed whether DFI had a potential impact on long-term maternal neonatal complications. Methods A total 5,271 women who underwent IVF treatment for the first time between October 1, 2020, July 31, 2023, were included from an academic...
Abstract Retinal ganglion cells are the bridging neurons between eye and central nervous system, transmitting visual signals to brain. The injury loss of retinal primary pathological changes in several degenerative diseases, including glaucoma, ischemic optic neuropathy, diabetic neuritis. In mammals, injured lack regenerative capacity undergo apoptotic cell death within a few days injury. Additionally, these exhibit limited ability, ultimately contributing vision impairment potentially...
Abstract Background Trophectoderm (TE) cell biopsy at the blastocyst stage is currently most common method used in preimplantation genetic testing for monogenic disorders (PGT-M). However, this approach may result wasting of some genetically unaffected embryos because only a proportion zygotes develop to stage. Unaffected embryos, which degenerated during blastomere-blastocyst transformation, give birth if transferred before and be great value women with low oocyte count. This study sought...
ABSTRACT After the coronavirus disease 2019 (COVID‐19) pandemic, postacute effects of severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection have gradually attracted attention. To precisely evaluate health status convalescent patients with COVID‐19, we analyzed symptom and proteome data 442 plasma samples from healthy controls, hospitalized patients, 6 or 12 months after SARS‐CoV‐2 infection. Symptoms analysis revealed distinct relationships in patients. Results protein expression levels...
Compared to regular tumor cells, cancer stem cells exhibit dangerous characteristics, including high proliferation, metastatic potential, and significantly increased in vivo tumorigenicity. Although some studies have emphasized the impact of microenvironment on cell stemness, they largely overlooked mechanical forces derived from stiffness surrounding extracellular matrix. Our previous research demonstrated that a 90 Pa soft fibrin matrix three-dimensional (3D) culture can induce become...
Purpose To evaluate the relationships between sperm DNA fragmentation index (DFI) and semen parameters its application in fresh embryos via vitro fertilization transfer. Methods A retrospective propensity score matching (PSM) study was conducted on 162 cycles of (IVF) or intracytoplasmic injection (ICSI) embryo transfer (fresh IVF/ICSI-ET) from 2020–2024. Results Spearman correlation analysis revealed a negative DFI motility (r = −0.44, p 3.32e−08), forward movement −0.46, 3.25e−09), normal...
With the development of healthcare industry, demand for medical services and protective equipment is boosted, causing generation rate infectious waste to increase rapidly. Therefore, it utmost importance decision makers effectively predict potential risks propose corresponding solutions. This paper investigates reverse logistics network optimization under conditions an uncertain proposal demand. Firstly, a prediction model based on SEIR epidemiological dynamics constructed, in which both...
Clinical research indicates that SARS-CoV-2 infection is linked to several neurological consequences, and the virus still spreading despite availability of vaccinations antiviral medications. To determine how hosts respond infection, we employed LC-MS/MS perform ubiquitinome proteome analyses brain cortexes from K18-
Abstract Lactylation, as a novel posttranslational modification, is essential for studying the functions and regulation of proteins in physiological pathological processes, well gaining in‐depth knowledge on occurrence development many diseases, including tumors. However, few studies have examined protein lactylation one whole organism. Thus, we studied global Caenorhabditis elegans to obtain an vivo lactylome. Using MS‐based platform, identified 1836 Class I (localization probabilities >...
Ubiquitylation, a critical post-translational modification, regulates various biological pathways. Despite its implications in diseases like cancer, the ubiquitinome of human hypothalamus remains inadequately explored. We conducted label-free analysis on samples from healthy elderly individuals, identifying 21,815 ubiquitylated sites across 5,314 proteins. Motif revealed specific residue preferences. Functional enrichment significant roles cellular processes, particularly transport and...
<title>Abstract</title> Background Trophectoderm (TE) cell biopsy at the blastocyst stage is currently predominant method used in preimplantation genetic testing for monogenic disorders (PGT-M). However, this approach may result discarding of genetically unaffected embryos due to fact that not all progress stage. This study aimed investigate advantages utilizing polar body (PB) females with disease-causing mutations and a limited number oocytes undergoing PGT-M. Methods Three couples...
The hippocampus has long been associated with cognition and memory function, the implications of lysine lactylation (Kla), a recently identified post-translational modification (PTM), in role remain largely unexplored.
Background Previous studies on the impact of mitochondrial DNA (mtDNA) copy number female infertility were limited and inconsistent.
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has infected hundreds of millions people all over the world and thus threatens human life. Clinical evidence shows that SARS‐CoV‐2 infection can cause several neurological consequences, but existing antiviral drugs vaccines have failed to stop its spread. Therefore, an understanding response hosts is vital find a resultful therapy. Here, we employed K18‐ hACE2 mouse model LC‐MS/MS systematically evaluate acetylomes brain...