A5049094340- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2023-2025
Background Historically, preclinical studies with rat models have been carried out only male animals. Current regulations require sex parity in experimental procedures. Several shown significant differences of liver fibrosis, but there is no data available end-stage disease. The aim was to describe sex-related a carbon tetrachloride (CCl 4 )-induced model cirrhosis ascites. Methods Fifty-two rats, 26 each sex, fed ad libitum phenobarbital-enriched drinking water (5 mmol/l). CCl administered...
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory develop precision medicine strategies, biomarker discovery patient stratification are unmet needs. MicroRNAs (miRNAs) small RNA molecules that negatively regulate gene expression modulate several biological processes, functioning as biomarkers for many diseases. Here, we identify...