A5077972176- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Galectins and Cancer Biology
- Microscopic Colitis
- Health and Lifestyle Studies
- Pregnancy and preeclampsia studies
- Nursing care and research
- Aging, Health, and Disability
- Birth, Development, and Health
University of the Basque Country
2023-2025
BioCruces Health research Institute
2023
Increasing evidence supports the role of placenta in neurodevelopment and onset neuropsychiatric disorders. Recently, mQTL iQTL maps have proven useful understanding relationships between SNPs GWAS that are not captured by eQTL. In this context, we propose part genetic predisposition to complex disorders acts through placental DNA methylation. We construct a public cis-mQTL database including 214,830 CpG sites calculated 368 fetal samples from INMA project, run cell type-, gestational age-...
Background Celiac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype or DQ2.5/DQ2.2 heterozygous. Both HLA-DQ2-positive high genetic and those that have developed disease altered intestinal microbiota, but it remains unclear whether these alterations a cause consequence of CeD. Objective To investigate potential bidirectional causality between...
Abstract Background Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consumption. HLA risk alleles explain 40% of the genetic component CeD, so there have been continuing efforts to uncover non-HLA loci can remaining heritability. As most autoimmune disorders, prevalence CeD significantly higher women. Here, we investigated possible involvement X chromosome on sex bias CeD. Methods We performed a chromosome-wide association...
Increasing evidence supports the role of placenta in neurodevelopment and potentially, later onset neuropsychiatric disorders. Recently, methylation quantitative trait loci (mQTL) interaction QTL (iQTL) maps have proven useful to understand SNP-genome wide association study (GWAS) relationships, otherwise missed by conventional expression QTLs. In this context, we propose that part genetic predisposition complex disorders acts through placental DNA (DNAm). We constructed first public...