A5047864568- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Optical Coherence Tomography Applications
- Surface Modification and Superhydrophobicity
- Advanced Nanomaterials in Catalysis
- Metabolomics and Mass Spectrometry Studies
- Photodynamic Therapy Research Studies
- Retinal and Macular Surgery
- Lanthanide and Transition Metal Complexes
- Autophagy in Disease and Therapy
- Electrocatalysts for Energy Conversion
- Per- and polyfluoroalkyl substances research
- Advanced battery technologies research
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Advanced Photocatalysis Techniques
- Cancer Immunotherapy and Biomarkers
- Nanocluster Synthesis and Applications
- Calcium Carbonate Crystallization and Inhibition
- Electrochemical Analysis and Applications
- Caching and Content Delivery
West China Hospital of Sichuan University
2017-2025
Sichuan University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
State Key Laboratory of Biotherapy
2019-2024
Tongji University
2019-2024
Huzhou University
2023-2024
University of Jinan
2021-2022
Sun Yat-sen University
2021-2022
West China Medical Center of Sichuan University
2021
South China University of Technology
2019
Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However, the therapeutic efficacy existing metabolism-regulating agents often compromised due to tolerance resulting from plasticity, as well their poor bioavailability and tumor-targetability. Inspired by inhibitive effect N-ethylmaleimide on mitochondrial function, dendronized-polymer-functionalized metal-phenolic nanomedicine (pOEG-b-D-SH@NP) encapsulating maleimide-modified doxorubicin (Mal-DOX)...
Cancer cells could be eradicated by promoting generation of excessive intracellular reactive oxygen species (ROS) via emerging nanomedicines. However, tumor heterogeneity and poor penetration nanomedicines often lead to diverse levels ROS production in the site, at a low level promote cell growth, thus diminishing therapeutic effect these Herein, we construct an amphiphilic block polymer-dendron conjugate-derived nanomedicine (Lap@pOEGMA-b-p(GFLG-Dendron-Ppa), GFLG-DP/Lap NPs) that...
Ammonia (NH3 ), known as one of the fundamental raw materials for manufacturing commodities such chemical fertilizers, dyes, ammunitions, pharmaceuticals, and textiles, exhibits a high hydrogen storage capacity ≈17.75%. Electrochemical nitrate reduction (NO3 RR) to valuable ammonia at ambient conditions is promising strategy facilitate artificial nitrogen cycle. Herein, copper-doped cobalt selenide nanosheets with selenium vacancies are reported robust highly efficient electrocatalyst...
Abstract Metabolic demand of cancer is quite unique compared to normal tissues and this an emerging hallmark cancer, which brings a potential opportunity discover drugs that target cell metabolism. Herein, the development dendronized pyropheophorbide (Ppa)‐conjugated polymer (DPP) reported, linear Ppa‐conjugated (LPP) reported as control. DPP found disturb cellular metabolism including increased energy depletion, dysfunctional H + regulation, decreased antioxidation, resulting in deficiency...
Abstract Immune response in the tumor microenvironment (TME) is an essential therapeutic factor for antitumor therapy. Herein, to improve immunostimulatory effects, photodynamic therapy (PDT) combined with AZD2281 trigger stimulator of interferon genes (STING)‐dependent immune responses. A synthetic branched polymer‐pyropheophorbide a (Ppa) conjugate (BGSSP) designed and developed redox/cathepsin B TME. This unique structure large molecular weight (MW) can self‐assemble into compact via...
Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design drug delivery systems. Herein, a polymer-dendron conjugate, POEGMA-b-p(GFLG-Dendron-Ppa) (GFLG-DP), is presented, which allows cathepsin-B-triggered stealthy-to-sticky structural transformation. The compositions ratios are optimized dissipative particle dynamics simulations. GFLG-DP displays tumor-specific transformation the consequently released dendron-Ppa found to effectively...
Abstract Amorphization and crystalline grain boundary engineering are adopted separately in improving the catalytic kinetics for water electrolysis. Yet, synergistic effect advance cooperated form of crystalline/amorphous interfaces (CAI) have rarely been elucidated insightfully. Herein, a trimetallic FeCo(NiS 2 ) 4 catalyst with numerous CAI (FeCo(NiS ‐C/A) is presented, which shows highly efficient activity toward both hydrogen oxygen evolution reactions (HER OER). Density functional...
Owing to the low efficacy of clinically used small-molecule gadolinium (Gd)-based magnetic resonance imaging (MRI) agents, we designed and explored biodegradable macromolecular conjugates as MRI contrast agents. The linear polymeric structure core-cross-linked formulation possessed different characteristics features, so prepared comparatively studied two kinds Gd-based N-(2-hydroxypropyl) methacrylamide (HPMA) systems (the pHPMA-DOTA-Gd one) using clinical agent diethylene-triamine...
The availability and the stability of current anticancer agents, particularly water-insoluble drugs, are still far from satisfactory. A widely used drug, gemcitabine (GEM), is so poorly stable in circulation that some polymeric drug-delivery systems have been under development for time to improve its therapeutic index. Herein, we designed, prepared, characterized a biodegradable amphiphilic block N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer–GEM conjugate-based nanoscale...
Novel magnetic resonance imaging (MRI) contrast agents with high sensitivity and good biocompatibility are required for the diagnosis of cancer. Herein, we prepared characterized gadolinium [Gd(III)]-labeled peptide dendron–hyaluronic acid (HA) conjugate-based hybrid (dendronized-HA–DOTA–Gd) by combining advantages HA dendron. The dendronized-HA–DOTA–Gd 3.8% Gd(III) as weight percentage showed a negative zeta potential (−35 mV). in vitro degradation results indicated that degraded into...
Inspired by natural saccharide-protein complexes, a stimuli-responsive biodegradable and branched glycopolymer-pyropheophorbide-a (Ppa) conjugate (BSP) with saccharide units for cancer therapy is constructed. A linear glycopolymeric (LSP), (BShP) from Ppa long carbon chains, (BHSP) based on poly[N-(2-hydroxypropyl) methacrylamide] (polyHPMA) without are prepared as controls. Through structure-activity relationship studies, BSP 3D network structure forms stable nanostructures via weak...
Abstract Nanozyme catalytic therapy for cancer treatments has become one of the heated topics, and therapeutic efficacy is highly correlated with their efficiency. In this work, three copper‐doped CeO 2 supports various structures as well crystal facets are developed to realize dual enzyme‐mimic activities, that superoxide dismutase (SOD) reduce radicals H O peroxidase (POD) transform ∙OH. The wire‐shaped /Cu‐W richest surface oxygen vacancies, a low level vacancy (Vo) formation energy,...
Abstract Oxygen evolution reaction (OER) is critical for optimizing renewable energy systems, including metal–air batteries and water electrolysis. One major challenge OER to develop durable cost‐effective electrocatalysts with high catalytic performance. Herein, a controllable ion‐exchange method synthesize amorphous zinc/cobalt–iron hydroxide‐based hollow nanowall arrays (A‐Zn/Co–Fe HNAs) derived from bimetallic metal–organic frameworks (MOFs) on carbon cloth reported. The characteristic...
Tumor cells are dominant in the nutritional competition tumor microenvironment, and their metabolic abnormalities often lead to microenvironmental acidosis nutrient deprivation, thereby impairing function of immune diminishing antitumor therapeutic effect. Herein, a branched polymeric conjugate its efficacy attenuating reported. Compared with control nanoparticles prepared from linear counterpart, branched-conjugate-based can more efficiently accumulate tissue interfere processes increase...
A PEGylated multistimuli-responsive dendritic copolymer-doxorubicin (DOX) prodrug-based nanoscale system was developed as a delivery model for hydrophobic drugs. In this system, PEGylation did not only prolong circulation of the in body (average half-life 14.6 h, four times longer than that free drug), but also allowed to aggregate into nanoparticles (NPs) because interactions between hydrophilic (polyethylene glycol) and (dendritic prodrug) moieties better uptake through endocytosis (around...
Smart nanoscale drug delivery systems have been investigated as potential candidates for vehicles. Here, we used a breast cancer model to determine if the enzyme-responsive Janus dendron (mPEGylated dendron-PVGLIG-DOX) conjugate-based system would be an effective and safe vehicle chemotherapy. To this end, prepared characterized matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via...
ABSTRACT Inflammation, as a complex biological response, can lead to tissue damage and pathological physiological changes, forming the basis for many chronic diseases. Stem cell‐derived exosomes (SC‐Exos), type of nanoscale extracellular vesicle, possess advantages such small volume, low immunogenicity, drug‐carrying capacity, demonstrating immense potential in field disease diagnostics therapeutics. Current studies indicate that SC‐Exos not only alleviate inflammatory diseases by...
Abstract An amphiphilic peptide dendrimer conjugated with gemcitabine (GEM), PEGylated dendron‐Gly‐Phe‐Leu‐Gly‐GEM (PEGylated dendron‐GFLG‐GEM), is developed as a nano‐prodrug for breast cancer therapy. The self‐assembled behavior observed under transmission electron microscopy and dynamic light scattering. negatively charged surface hydrodynamic size of the nanosized prodrug supported that can maintain stability GEM during circulation accumulate in tumor tissue. Drug release assays are...