Abstract Primary pulmonary mucosa‐associated lymphoid tissue‐derived (MALT) lymphoma is a rare disease with favorable prognosis. However, its clinical characteristics, diagnosis, treatment, and prognoses remain unclear. We retrospectively analyzed 80 patients pathologically confirmed MALT from 2006 to 2018. The treatments, of all the were recorded. Patients stratified into surgery biopsy groups, respectively, evaluate role in diagnosis treatment lymphoma. compared between different...

Lung cancer is one of the most frequent malignant tumors, with top morbidity and mortality, in China. Calpain family regulates cellular processes including migration invasion. However, role Calpain-2 non-small cell lung (NSCLC) remains unclear. This study aims to explore bio-function on NSCLC chemoresistance paclitaxel. In this study, Immunohistochemistry, RT-qPCR Western blot were performed detect expression related pathway protein NSCLC. The Kaplan-Meier product limit estimator Cox...

Abstract Background Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive tumor. The inflammatory environment plays an important role in the tumorigenesis and development ESCC. Cancer stem cells are a small group tumor with characteristics, which can potentially hinder management treatment. Methods ELISA was performed to detect lipopolysaccharide concentration tissues. qPCR, Western blot, FACS, Immunohistochemistry, Immunofluorescence Dot blot were applied target genes...

The aim of the current study was to investigate effects resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in human osteosarcoma line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 40 µmol/l) for times (24, 48 72 h). inhibitory effect observed using methyl thiazolyl tetrazolium (MTT) colorimetry. VEGF determined real-time polymerase chain reaction (RT-PCR) western blot analysis. increased as concentration increased....

The present study aims to analyze the main reasons that lead failure of bone tuberculosis (TB) surgery and efficacy reoperation. A total 3,000 cases TB patients were examined retrospectively. Of these, 180 had recurrence, including 135 spinal 45 limb TB. Preoperative indicators duration anti-TB chemotherapy, nutritional conditions, temperature conditions erythrocyte sedimentation rate, medication time postoperative recurrence statistically analyzed. all with reoperation, 176 cured, four...

Prostaglandin E2 (PGE2) receptor 4 (EP4) is one of four EP receptors commonly upregulated in the tumor microenvironment and plays vital roles stimulating cell proliferation, invasion, metastasis. Biochemical blockade PGE2–EP4 signaling pathway a promising strategy for controlling inflammatory immune related disorders. Recently combination therapies EP4 antagonists with anti-PD-1 or chemotherapy agents have emerged clinical studies lung, breast, colon, pancreatic cancers. Herein, novel series...

Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant digestive tumors around world. We previously demonstrated that eIF3b could promote progression ESCC. The exact mechanisms underlying these effects remained unknown.Quantitative proteomics was applied to detect potential targets Eukaryotic translation initiation factor 3 subunit b (eIF3b). RT-qPCR and Western blot were performed expression targeted gene pathway related genes. RNA-immunoprecipitation verify binding...

The aim of the present study was to investigate effect characteristic elements matrix attachment region (MAR) on transgene expression. Human β‑globin MAR obtained by PCR amplification. A splicing fragment containing all artificially synthesized and then cloned into eukaryotic expression vector. Following digestion sequence identification, we transfected Chinese hamster ovary (CHO) cells with two vectors, screened for transformation stable cells. level analyzed ELISA, copy numbers CAT gene...

This study aims to evaluate the cytotoxicity and damage of dexamethasone (DEX) on rat pheochromocytoma (PC12) cells by determining cell viability, Hoechst 33342 staining, mitochondrial depolarization assays, opened permeability transition pores (MPTPs) detection, measurement Caspase-3 Bcl-2 activities. The results show that DEX inhibits PC12 growth decreases their viability in a remarkable dose-dependent manner. Our also reveal exposure causes morphologic changes, opening MPTPs...

Elderly patients undergoing cardiac operation often suffer various metabolic comorbidities, such as diabetes mellitus (DM) and obesity. The disorders in these individuals are widely considered to be possible predisposing factors for unfavourable prognosis. This retrospective study was aimed determine the association of diseases with mortality elderly after coronary artery bypass grafting (CABG) identify protective or risk related their short- long-term survival.Totally 684 aged 75 years...

Abstract Background: Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive tumor. The inflammatory environment plays an important role in the tumorigenesis and development ESCC. Cancer stem cells are a small group tumor with characteristics, which can potentially hinder management treatment. Methods: ELISA was performed to detect lipopolysaccharide concentration tissues. qPCR, Western blot, FACS, Immunohistochemistry, Immunofluorescence Dot blot were applied target genes...

Objective. To discuss the effect of clinical pathway single disease quota payment mode on medical costs. Methods. Collecting total cost, drug costs, and inspection fee details gallbladder benign surgery, acute simple appendicitis operation, planned cesarean section during 2009 2011 in Qianjiang Central Hospital; analyzing treatment costs diseases before after implementation using spss11.0. Results. Compared to incurred prior management, there was a dramatic decline cost expenses section....

Abstract Background Chronic inflammation generates a tumor-supporting microenvironment, but it remains unclear whether and how the persistent drives genetic abnormalities leading to occurrence progression of esophageal squamous cell carcinoma (ESCC). Methods By global RNA-sequncing, we screened genes related ESCC with stimulation pro-inflammatory factor, interleukin (IL)-1β, identified FRAS1-related extracellular matrix protein (FREM)2 as oncogene. Flow cytometry was used detect expression...

Abstract Background Patients with cirrhosis are prone to mental and psychological problems. However, data on problems in patients during the coronavirus disease 2019 (COVID-19) pandemic lacking. Therefore, we aimed investigate prevalence risk factors of anxiety depression this population. Methods The Patient Health Questionnaire-9 Scale Generalized Anxiety Disorder 7-item scale were used collect health cross-sectional study. Multivariate logistic regression analysis was performed evaluate...

Abstract Background Renal dysfunction is related to the poor outcomes of cardiac surgery. Preoperative occult renal (PORD) defined as patients with normal serum creatinine (Scr) but glomerular filtration rate (GFR) less than 60 ml/min/1.73m 2 . However, there no report on prognosis elderly PORD undergoing coronary artery bypass grafting (CABG). This problem deserves further exploration. Methods Totally 1103 CABG Scr and age ≥ 70 years old were enrolled. The estimated GFR (eGFR) each patient...

In complex and jamming scenarios, the efficiency anti-interference capability are crucial criteria for evaluating lidar systems. This paper thoroughly investigates ranging performance, efficiency, abilities of three types single photon systems: pulse accumulation (PASP) lidar, pseudo-random (PRSP) chaos (CSP) lidar. The simulation results reveal that CSP is superior or comparable to PASP PRSP in terms detection accuracy, precision, range under same mean transmitting power. To assess these...

Aiming at the problem that laser coherent detection system is easy to be annihilated in noise long-distance and complex environment, resulting unable extract effective information, In this paper, pulse compression theory matched filter principle are analyzed, a target high-precision LFM model suitable for proposed, by transmitting linear frequency modulation signal, combined with algorithm process echo realizes distance solution under condition of low signal-to-noise ratio. At same time,...