John Michael Sweetnam

ORCID: 0009-0002-1037-8085
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About
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Research Areas
  • Alzheimer's disease research and treatments
  • Global Cancer Incidence and Screening
  • Prion Diseases and Protein Misfolding
  • Gastric Cancer Management and Outcomes
  • Colorectal Cancer Screening and Detection
  • Lung Cancer Diagnosis and Treatment
  • Amyloidosis: Diagnosis, Treatment, Outcomes

Medical University of South Carolina
2024

University of Georgia
2014

Hirano bodies are actin-rich paracrystalline inclusions found in brains of patients with Alzheimer's disease (AD), frontotemporal dementia (FTD), and normal aged individuals. Although studies post-mortem brain tissue provide clues etiology, the physiological function remains unknown. A cell culture model was utilized to study interactions mutant tau proteins, bodies, GSK3β human astrocytoma cells. Most variants showed co-localization bodies. Cosedimentation assays revealed this interaction...

10.1186/1471-2202-15-74 article EN cc-by BMC Neuroscience 2014-06-14

10.1016/j.chpulm.2023.100030 article EN cc-by-nc-nd CHEST Pulmonary 2023-11-23
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