A5078128920- Smoking Behavior and Cessation
- Advanced Chemical Sensor Technologies
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Biochemical and Molecular Research
- Toxic Organic Pollutants Impact
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Metabolomics and Mass Spectrometry Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Carcinogens and Genotoxicity Assessment
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Biosimilars and Bioanalytical Methods
- Antibiotics Pharmacokinetics and Efficacy
- Mass Spectrometry Techniques and Applications
- Fungal Plant Pathogen Control
- Neuroscience of respiration and sleep
- Lung Cancer Treatments and Mutations
- Indoor Air Quality and Microbial Exposure
- Chemical and Physical Properties in Aqueous Solutions
- Liver Disease Diagnosis and Treatment
- Sulfur Compounds in Biology
- Lipid metabolism and disorders
- Macrophage Migration Inhibitory Factor
Novartis (United States)
2021-2024
Tris Pharma (United States)
2024
Novartis (Switzerland)
2012-2021
Novartis Institutes for BioMedical Research
2021
Boston Biomedical Research Institute
2021
Bristol-Myers Squibb (Germany)
2018
Chugai Pharma (United States)
2018
Boehringer Ingelheim (Switzerland)
2018
Roche (Switzerland)
2018
Pfizer (United States)
2018
An analytical procedure was developed for the analysis of 1,3-butadiene, acrolein, isoprene, benzene and toluene in gas phase cigarette smoke environmental tobacco (ETS) utilizing cryogenic chromatography-mass selective detection (GC-MSD). The MSD operated ion monitoring (SIM) mode. compounds interest eluted less than 15 min. freshly generated mainstream introduced into GC-MSD via a 10-port sampling valve on puff-by-puff basis. This method minimizes ageing smoke. levels 1,3-butadiene ranged...
A gas chromatography, negative ion chemical ionization mass spectrometry (GC-NICI-MS) based assay for tobacco-specific nitrosamine adducts of DNA is described. The on the observation that acid hydrolysis from animals treated with nitrosamines releases 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB). HPB and internal standard [4,4-D2]HPB are derivatized pentafluorobenzoyl chloride resulting HPB-pentafluorobenzoate purified by high-performance liquid chromatography prior to GC-NICI-MS analysis. human...
Background The present study was conducted among Chinese workers employed in glue- and shoe-making factories who had an average daily personal benzene exposure of 31±26 ppm (mean±SD). metabolites monitored were S-phenylmercapturic acid (S-PMA), trans, trans-muconic (t,t-MA), hydroquinone (HQ), catechol (CAT), 1,2,4-trihydroxybenzene (benzene triol, BT), phenol. Methods S-PMA, t,t-MA, HQ, CAT, BT quantified by HPLC-tandem mass spectrometry. Phenol measured GC-MS. Results Levels (except BT)...
To investigate how various levels of exposure affect the metabolic activation pathways benzene in humans and to examine relationship between urinary metabolites other biological markers, we have developed a sensitive specific liquid chromatographic–tandem mass spectrometric assay for simultaneous quantitation S-phenylmercapturic acid (S-PMA) trans,trans-muconic (t,t-MA). The involves spiking urine samples with [13C6]S-PMA [13C6]t,t-MA as internal standards clean up by solid-phase extraction...
Growth Differentiation Factor 15 (GDF15), a divergent member of the TGF-β superfamily, signals via hindbrain glial-derived neurotrophic factor receptor alpha-like and rearranged during transfection co-receptor (GFRAL-RET) complex. In nonclinical species, GDF15 is potent anorexigen leading to substantial weight loss. MBL949 half-life extended recombinant human dimer.
The metabolism, pharmacokinetics, and excretion of [<sup>14</sup>C]indacaterol were investigated in healthy male subjects. Although indacaterol is administered to patients via inhalation, the dose this study was orally. This done avoid complications concerns associated with administration a radiolabeled compound inhalation route. submilligram doses made metabolite identification structural elucidation by mass spectrometry especially challenging. In serum, mean <i>t</i><sub>max</sub>,...
Tobacco and mainstream smoke of USSR cigarettes were analyzed for carcinogens. The pH values suspensions the tobacco (5.4-5.6) nitrate content tobaccos (0.4-1.7%) as expected flue-cured sun-cured mixtures thereof. nicotine levels cigarette (0.76-0.94%) total alkaloid (0.85-1.08%) relatively low compared with used in Western European US cigarettes. concentrations tobacco-specific N-nitrosamines also (N'-nitrosonornicotine 0.36-0.85 microgram/g) those bright, oriental blended countries (0.3-19...
Drug-to-antibody ratio (DAR) determination is critical for development of antibody-drug conjugates (ADCs). This work presents a middle-up LC-MS approach DAR analysis using prelabeled capture beads and in-house fabricated slit-plates. Methodology & Results: Cysteine, engineered cysteine disulfide-linked ADCs, each with two different linker payloads, were immunocaptured digested to scFc F(ab')2 fragments. At this point, ADCs analyzed while reduced LC Fd' fragments analysis. Results precise,...
2549 Background: Panobinostat (PAN), a hydroxamic acid derivative, is potent pan-deacetylase inhibitor, demonstrating anti-tumor activities in wide variety of preclinical models and showing promising clinical activity. This study elucidates the metabolic elimination pathways PAN using [ 14 C]-PAN. Methods: Four patients with advanced cancer received single oral 20 mg dose C]-PAN (50 μCi). Whole blood, plasma, urine, feces were collected over 7 days. Total radioactivity was measured excreta...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalyses of steam distillates and aqueous extracts smokeless tobaccoEdmond J. LaVoie, Patricia Tucciarone, Mark Kagan, John D. Adams, Dietrich HoffmannCite this: Agric. Food Chem. 1989, 37, 1, 154–157Publication Date (Print):January 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jf00085a036https://doi.org/10.1021/jf00085a036research-articleACS PublicationsRequest reuse...
Tropifexor (NVP-LJN452) is a highly potent, selective, nonsteroidal, non-bile acid farnesoid X receptor agonist for the treatment of nonalcoholic steatohepatitis. Its absorption, metabolism, and excretion were studied after 1-mg oral dose [14C]tropifexor was given to four healthy male subjects. Mass balance achieved with ∼94% administered recovered in excreta through 312-hour collection period. Fecal tropifexor-related radioactivity played major role (∼65% total dose). reached maximum blood...
The clinical immunogenicity assessment for complex multidomain biological drugs is challenging due to multiple factors that must be taken into consideration. Here, we describe a strategy overcome bioanalytical challenges in order assess anti-drug antibodies (ADA) novel and unique chemically modified protein therapeutic. A risk-centered approach was adopted evaluate the immunogenic response version of human growth differentiation factor 15 (GDF15) connected an albumin-binding fatty acid via...
Abstract Pradigastat, a diacylglycerol acyltransferase 1 inhibitor, is being developed for the treatment of familial chylomicronemia syndrome. The results two studies that evaluated effect food on oral bioavailability pradigastat using randomized, open‐label, parallel group designs in healthy subjects ( n = 24/treatment/study) are presented. In study 1, single dose 20 mg was administered under fasted condition or with high‐fat meal. 2, 40 low‐ At dose, C max and AUC last increased by 38%...