A5027211161- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- Geotechnical and construction materials studies
- RNA Research and Splicing
- BIM and Construction Integration
- Reproductive Biology and Fertility
- RNA and protein synthesis mechanisms
- Urban and Freight Transport Logistics
- Underground infrastructure and sustainability
- Climate change and permafrost
- Viral Infections and Immunology Research
- Geotechnical Engineering and Analysis
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
Loyola Marymount University
2020-2022
Programmed -1 ribosomal frameshifts (-1 PRFs) are commonly used by viruses to regulate their enzymatic and structural protein levels. Human T-cell leukemia virus type 1 (HTLV-1) is a carcinogenic retrovirus that uses two independent PRFs express viral enzymes critical establishing new HTLV-1 infections. How the cis-acting RNA elements in this transcript function induce frameshifting unknown. The objective of work was conclusively define 3' boundary within pro-pol frameshift site. We...
The Inuvik Airport access road is a section of the Dempster Highway which extends from to junction MacKenzie Road within town Inuvik. As result an increase in mean annual air temperature approximately 3°C 4°C over last five decades, active layer thickness embankments region has increased considerably. led intensifying various earth processes on surface and embankment slopes. In recent years, distress/failures slopes had been observed at sections along road. Numerous transverse cracks were...
The human T-lymphotropic virus type 1 (HTLV-1) RNA genome includes two programmed -1 ribosomal frameshift (-1 PRF) sites. These sites allow ribosomes access to alternate reading frames encoding critical viral enzymes. gag-proframeshift site a slippery sequence, spacer, and stem-loop structure. How the acts promote frameshifting is unclear. Previous HTLV-2 research showed that changes gag-pro thermodynamic stability influenced its efficiency modest degree. There substantial conservation...