A5058348825- Chronic Kidney Disease and Diabetes
- Intensive Care Unit Cognitive Disorders
- Renin-Angiotensin System Studies
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Synthesis and Catalytic Reactions
- Gut microbiota and health
- Phagocytosis and Immune Regulation
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Palliative Care and End-of-Life Issues
- Cell Adhesion Molecules Research
- Olfactory and Sensory Function Studies
- Dialysis and Renal Disease Management
- Tryptophan and brain disorders
- Vagus Nerve Stimulation Research
- Extracellular vesicles in disease
- Protease and Inhibitor Mechanisms
Johns Hopkins University
2020-2024
Johns Hopkins Medicine
2020-2023
Extracellular vesicles (EVs) are involved in intercellular communication, transporting proteins and nucleic acids to proximal distal regions. There is evidence of glycosylation influencing protein routing into EVs; however, the impact aberrant cellular glycotransferase expression on EV profiles has yet be evaluated. In this study, we paired extracellular vesicle characterization quantitative proteomics determine systemic altered α(1,6)fucosyltranferase (FUT8) prostate cancer-derived EVs. Our...
Microbes are implicated in a variety of host physiological and pathophysiological processes. In this study, we tested the hypothesis that microbes modulate glomerular filtration rate (GFR). Microbiota were depleted mice using oral antibiotics (ABX; mixture ampicillin, neomycin, vancomycin). GFR was significantly increased ABX-treated mice. To confirm increase due to decreased microbes, also measured germ-free (GF) GF as compared both conventional conventionalized (CGF) We next used murine...