A5098961536- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Effects of Radiation Exposure
- Prostate Cancer Treatment and Research
- Nutrition, Genetics, and Disease
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Heat shock proteins research
- Metabolomics and Mass Spectrometry Studies
University of Nebraska Medical Center
2024-2025
Radiation causes damage to normal tissues that leads increased oxidative stress, inflammation, and fibrosis, highlighting the need for selective radioprotection of healthy without hindering radiotherapy effectiveness in cancer. This study shows adiponectin, an adipokine secreted by adipocytes, protects from radiation vitro vivo. Specifically, adiponectin (APN) reduces chronic stress fibrosis irradiated mice. Importantly, APN also conferred no protection prostate cancer cells. Adipose tissue...
Acute radiation syndrome (ARS) occurs when hematopoietic or gastrointestinal cells are damaged by exposure causing DNA damage to the bone marrow and epithelial stem cell populations. In these highly proliferative types, inhibits repopulation. humans animals, this inability regenerate is lethal. Within manuscript, several compounds, Amifostine, Captopril, Ciprofloxacin, PrC-210, 5-AED (5-androstene-3β,17β-diol), 5-AET (5-androstene-3β,7β,17B-triol), assessed for their ability protect against...