A5069418102- Malaria Research and Control
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- HIV Research and Treatment
Chinese University of Hong Kong, Shenzhen
2024
Boston Children's Hospital
2000
Flaviviruses encode a conserved, membrane-associated nonstructural protein 1 (NS1) with replication and immune evasion functions. The current knowledge of secreted NS1 (sNS1) oligomers is based on several low-resolution structures, thus hindering the development drugs vaccines against flaviviruses. Here, we revealed that recombinant sNS1 from flaviviruses exists in dynamic equilibrium dimer-tetramer-hexamer states. Two DENV4 hexameric structures tetrameric multiple were solved at atomic...
Herpes simplex virus type 1 (HSV-1) plasmid vectors have a number of attractive features for gene transfer into neurons. In particular, the large size HSV-1 genome suggests that might be designed to accommodate inserts. We now report construction and characterization 51 kb vector. This vector was efficiently packaged particles using helper virus-free packaging system. The structure DNA verified by both Southern blot PCR analyses. A stock microinjected rat striatum, rats were sacrificed at 4...