A5019839732- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- HER2/EGFR in Cancer Research
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Pharmacogenetics and Drug Metabolism
- Glycosylation and Glycoproteins Research
- Inflammatory mediators and NSAID effects
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Chemical Synthesis and Analysis
- Ferrocene Chemistry and Applications
Andhra University
2023
Akebia Therapeutics (United States)
2019-2020
A new Pt(<sc>ii</sc>) prodrug, developed by a combined drug development approach.
Naringenin is one of the major components grapefruit juice. It has a broad spectrum pharmacological activities, and many studies report that juice inhibits cytochrome P450 (CYP) 3A4 leading to drug interactions. was profiled through various in vitro like metabolic stability glucuronidation rat human liver microsomes while, CYP inhibition using microsomes. In addition, pharmacokinetic profiling conducted upon intravenous (i.v.) oral administration rats. undergoes both phase I II metabolism...
Abstract Introduction: Cancer immunotherapy is the emerging paradigm in search for a cure cancer. AT1965 novel therapeutic that demonstrates remarkable anti-tumor activity across different preclinical tumor models, mediated through activation of B-cells. In this study, we have evaluated metabolism, pharmacokinetics (PK) and toxicity rodent non-rodent species. Methods: metabolism was studied rodent, canine primate liver microsomes. The PK determined 4T1 bearing female Balb/c mice; Sprague...