A5072262565- RNA modifications and cancer
- Travel-related health issues
- Hormonal and reproductive studies
- Epigenetics and DNA Methylation
- Island Studies and Pacific Affairs
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Hormonal Regulation and Hypertension
- Genetic Syndromes and Imprinting
- Herpesvirus Infections and Treatments
- Sexual Differentiation and Disorders
- Cytomegalovirus and herpesvirus research
- Stress Responses and Cortisol
- Ovarian function and disorders
- Diabetes and associated disorders
Institut Pasteur
2021-2025
Centre National de la Recherche Scientifique
2021-2025
Université Paris Cité
2022-2025
Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how blood DNA methylome 884 adults is affected by sequence variation, age, sex 139 relating life habits immunity. Furthermore, investigated whether these effects mediated or not cellular composition, measured deep immunophenotyping. We show methylation differs substantially between naïve...
Steroid hormone levels vary greatly among individuals, between sexes, with age, and across health disease. What drives variance in steroid hormones how they individuals over time are not well studied. To address these questions, we measured 17 a sex-balanced cohort of 949 healthy donors aged 20 to 69 years. We investigated associations biological sex, clinical demographic data, genetics, plasma proteomics. were strongly affected by sex high number lifestyle habits. Key observations the broad...
Human immune responses are highly variable from one individual to another, with these differences determined by both genetic and environmental factors. We previously established the Milieu Interieur cohort define boundaries of healthy identify quantify its different determinants. From this 1,000 well-defined donors, we have identified multiple factors that associated phenotypes. Crucially, associations were observed in a context, as defined strict inclusion exclusion criteria. To assess how...
Background French Polynesia is a overseas collectivity in the Southeast Pacific, comprising 75 inhabited islands across five archipelagoes. The human settlement of region corresponds to last massive migration humans empty territories, but its timeline still debated. Despite their recent population history and geographical isolation, inhabitants experience health issues similar those continental countries. Modern lifestyles increased longevity have led rise non-communicable diseases (NCDs)...
Abstract Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how blood DNA methylome 884 adults is affected by sequence variation, age, sex 139 relating life habits immunity. Furthermore, investigated whether these effects mediated or not cellular composition, measured deep immunophenotyping. We show methylation differs substantially between...
Summary Immunoglobulins are among the most important anti-viral effectors of human immune system. The biological mechanisms underlying antibody production and maintenance relatively well understood. However, a broader model how host intrinsic factors external processes influence humoral responses to viral infections is lacking. Here, we investigate age, sex, genetics, health-related habits, relate repertoire healthy humans. We used VirScan, high-throughput technology based on phage-display...
Abstract Steroid hormone levels vary greatly among individuals, between the sexes, with age, and across health disease states. Nevertheless, what drives variance in steroid hormones and, globally, how an individual over time are not well-studied. To address this fundamental gap knowledge, we measured of 17 a sex-balanced cohort 949 healthy donors ranging age from 20-69 years. We investigated associations biological sex, clinical demographic data, genetics, proteomics. were strongly affected...
Abstract Background French Polynesia is a overseas collectivity in the Southeast Pacific, comprising 75 inhabited islands across five archipelagoes. The human settlement of region corresponds to last massive migration humans empty territories, but its timeline still debated. Despite their recent population history and geographical isolation, inhabitants experience health issues similar those continental countries. Modern lifestyles increased longevity have led rise non-communicable diseases...