A5086472114- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- interferon and immune responses
- Jewish and Middle Eastern Studies
- Gene expression and cancer classification
- Jewish Identity and Society
- Molecular Biology Techniques and Applications
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
Tel Aviv University
2023-2025
New York University Press
2017-2021
Cambridge University Press
2017-2021
Harvard University Press
2017-2021
Edmonds Community College
2019-2021
Episcopal Divinity School
2017-2018
Bridge University
2018
University of Cambridge
2018
Ataxia–telangiectasia (A-T) is a pleiotropic genome instability syndrome resulting from the loss of homeostatic protein kinase ATM. The complex phenotype A-T includes progressive cerebellar degeneration, immunodeficiency, gonadal atrophy, interstitial lung disease, cancer predisposition, endocrine abnormalities, chromosomal instability, radiosensitivity, and segmental premature aging. Cultured skin fibroblasts patients exhibit senescence, highlighting association between cellular We found...
Abstract Aneuploidy results in a stoichiometric imbalance of protein complexes that jeopardizes cellular fitness. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RNA and levels, but underlying molecular mechanisms remain unknown. Here, we dissected multiple diploid vs. aneuploid cell models. We found cope with transcriptional burden increasing several degradation pathways, are consequently more sensitive perturbation degradation. At level, mitigate...
Abstract Background Aneuploidy, an abnormal number of chromosomes within a cell, is hallmark cancer. Patterns aneuploidy differ across cancers, yet are similar in cancers affecting closely related tissues. The selection pressures underlying patterns not fully understood, hindering our understanding cancer development and progression. Results Here, we apply interpretable machine learning methods to study tissue-selective patterns. We define 20 types features corresponding genomic attributes...
Abstract Aneuploidy, an abnormal number of chromosomes within a cell, is considered hallmark cancer. Patterns aneuploidy differ across cancers, yet are similar in cancers affecting closely-related tissues. The selection pressures underlying patterns not fully understood, hindering our understanding cancer development and progression. Here, we applied interpretable machine learning (ML) methods to study tissue-selective patterns. We defined 20 types features normal tissues, used them model...
<div>Abstract<p>Aneuploidy results in a stoichiometric imbalance of protein complexes that jeopardizes cellular fitness. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RNA and levels, but underlying molecular mechanisms remain unknown. In this study, we dissected multiple diploid <i>versus</i> aneuploid cell models. We found cope with transcriptional burden increasing several degradation pathways, are consequently more...
<p>Supplementary Figure 1: Dosage compensation in trisomic cells occurs at both mRNA and protein levels (related to Fig. 1). Supplementary 2: RNA degradation does not confound the results of differential gene expression analyses 2). 3: Aneuploid clones activate nonsense-mediated decay (NMD) pathway, depend on it for downregulating their 3). 4: Increased dependency pathway is a general feature aneuploid 5: Trisomic miRNA-mediated 4). 6: miRNA machinery cofactors PRKRA TARBP2 7: Multiple...
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A Woman's Life: Pauline Wengeroff and Memoirs of a Grandmother, continues Shulamit Magnus’ ongoing project to bring the writings nineteenth-century Russian Jewish woman life. This text buil...
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