The proto-oncogene c- fos is expressed in neurons response to direct stimulation by growth factors and neurotransmitters. In order determine whether the protein (Fos) Fos-related proteins can be induced polysynaptic activation, rat hindlimb motor/sensory cortex was stimulated electrically Fos expression examined immunohistochemically. Three hours after onset of stimulation, focal nuclear staining seen motor sensory thalamus, pontine nuclei, globus pallidus, cerebellum. Moreover, 24-hour...

Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to 24-hr day/night cycle periodic environmental light cues. We show that alters immunoreactive levels of transcriptional regulatory protein, Fos, albino rats. Photic regulation Fos immunoreactivity does not occur other retino-recipient brain areas except for intergeniculate leaflet, which appears be involved mediating some complex effects on expressed rhythms. Our...

An integrative approach for managing a patient with cancer should target the multiple biochemical and physiologic pathways that support tumour development minimize normal-tissue toxicity. Angiogenesis is key process in promotion of cancer. Many natural health products inhibit angiogenesis also manifest other anticancer activities. The present article focuses on have high degree anti-angiogenic activity, but it describes some many actions these agents can progression reduce risk metastasis....

The value of early postoperative feeding with an elemental diet was assessed in 30 patients after major gastrointestinal operations. were allocated at random to conventional treatment (control group) or the (ED group). clinical and metabolic course 15 ED group significantly better than that controls. Patients lost less weight had a shorter stay hospital. Negative nitrogen balance more pronounced control throughout seven days. Energy intake higher group. Provided is used caution, it may be...

Immunoreactive calcitonin (CT), indistinguishable from human CT-(1-32) and its sulfoxide, has been identified in extracts of the hypothalamus, pituitary, thyroid obtained subjects at autopsy. DCT concentrations were highest a region encompassing posterior median eminence, pituitary; intermediate substantia nigra, anterior globus pallidus, inferior colliculus; low caudate nucleus, hippocampus, amygdala, cerebral cerebellar cortices. Specific CT binding measured with 125I-labeled salmon was...

Induction of the 70-kDa heat shock protein (HSP70) was demonstrated immunocytochemically in adult rats 4 h to 7 days following temporary middle cerebral artery (MCA) occlusions lasting 30, 60, or 90 min. Maximal HSP70 induction occurred ∼24 ischemia. Thirty minutes ischemia induced neurons throughout cortex MCA distribution, whereas min penumbra. endothelial cells infarcted neocortex 60–90 occlusion, and regions lateral striatum 30–90 occlusion. hsp70 mRNA distribution a lesser extent at 2 3...

Huntington disease (HD) is an autosomal dominant hereditary disorder characterized by premature cell death, predominantly in the neostriatum. Decreased concentrations of several neurotransmitters and neuropeptides have been reported basal ganglia disease. We now report that radioimmunoassayable somatostatin are increased extracts caudate (mean +/- standard error mean, ng/gm net weight; 247 24 versus 85 11), putamen (275 48 74 external globus pallidus (100 10 27 6), internal (108 21 8) The...

Selective neurotoxins have been of value in providing a means for specifically interfering with the actions endogenous neurotransmitter candidates. Others shown cysteamine (CSH) to deplete gastrointestinal tract and hypothalamus rats immunoreactive somatostatin, suggesting toxic action that compound directed against somatostatin-containing cells. The present study further defines on somatostatin central nervous system. (CNS). Cysteamine hydrochloride administered subcutaneously results...

Abstract Excitatory amino acids have been implicated in ischemic neuronal injury. To test this hypothesis neonatal hypoxia‐ischemia, lesions of the cortex and striatum were induced 7‐day‐old rats by unilaterally ligating their carotid arteries subjecting them to hypoxic conditions for 2 hours. Brains examined 1 week later demonstrated, within regions damage, a striking preservation neurons that stained histochemically nicotinamide adenine dinu‐cleotide phosphate diaphorase (NADPH‐d)...

Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced c-fos, junB, and c-jun immediate early gene mRNAs hsp70 heat shock mRNA brain. In situ hybridization studies showed that c-fos junB were throughout all of the cortex at 1 4 h following MCA occlusion. was core margins ischemia. By 24 h, there little expression c-jun, infarct; modest induction diffuse outside infarct. also these genes subcortical structures. ipsilateral medial striatum, most thalamus including...

Chemotherapy induced peripheral neuropathy (CIPN) occurs in 10 to 20% of cancer patients treated with neurotoxic chemotherapy. A mixture sensory, sensorimotor and autonomic nervous system dysfunction can occur, resulting deterioration function worsened quality life. major feature is discomfort pain. Early termination treatment dose reduction chemotherapy may be necessary. The clinical course variable depends on the agents their cumulative dose. Although symptoms resolve completely, most CIPN...

Journal Article Evidence that Reduced Growth Hormone Secretion Observed in Monosodium Glutamate-Treated Rats Is the Result of a Deficiency Hormone-Releasing Factor Get access W. J. MILLARD, MILLARD 1Department Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, 02114 Search for other works by this author on: Oxford Academic Google Scholar B. MARTIN, JR.,, JR., AUDET, AUDET S. M. SAGAR, SAGAR MARTIN Endocrinology, Volume 110, Issue 2, 1 February 1982, Pages 540–550,...

Abstract Fos, the protein product of c‐ fos gene, is induced in neurons response to a variety stimuli. In order see if Fos could be used map activity brain, pattern staining was compared ( 14 C) 2‐deoxyglucose (2DG) uptake seventh and eighth lobules cerebellum during electrical stimulation cerebral cortex. Electrical hindlimb motor/sensory cortex awake rats increased 2DG contralateral ipsilateral cerebellum. The largest increases occurred granule cell patches copula pyramidis (Cop P) pyramis...