A5100719989- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- Plant-based Medicinal Research
- Cancer-related Molecular Pathways
- Botanical Studies and Applications
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Toxin Mechanisms and Immunotoxins
- Synthesis of Organic Compounds
- 14-3-3 protein interactions
- Bioactive Natural Diterpenoids Research
- Traditional Chinese Medicine Analysis
- Fungal Plant Pathogen Control
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
Xinjiang Medical University
2023-2024
West China Hospital of Sichuan University
2010
Sichuan University
2010
This study involved the design and synthesis of 21 new nitrogen-containing heterocyclic chalcone derivatives utilizing active substructure splicing principle, with glycyrrhiza serving as lead compound. The targets these were VEGFR-2 P-gp, their efficacy against cervical cancer was evaluated. Following preliminary conformational analysis, compound 6f ((E)-1-(2-hydroxy-5-((4-hydroxypiperidin-1-yl)methyl)-4-methoxyphenyl)-3-(4-((4-methylpiperidin-1-yl)methyl)phenyl)prop-2-en-1-one) exhibited...
In this study, a collection of newly developed α-methylchalcone derivatives were synthesized and assessed for their inhibitory potential against human cervical cancer cell lines (HeLa, SiHa, C33A) as well normal epithelial cells (H8). Notably, compound 3k exhibited substantial effects on both HeLa HeLa/DDP while demonstrating lower toxicity toward H8 cells. Furthermore, the was found to induce apoptosis in also inhibiting G2/M phase, resulting decrease invasion migration capabilities these...
Several novel fluorinated chalcone derivatives were synthesized, and their in vitro anticervical cancer activity mechanism of action investigated using the parent nucleus licorice as lead compound backbone MDM2-p53 target. In this study, 16 (3a-3r) designed synthesized by molecular docking technology based on scaffold apoptosis regulatory target MDM2-p53. The structures these compounds confirmed 1H-NMR, 13C-NMR, HR-ESI-MS. inhibitory effects proliferation three human cervical cell lines...