A5092772578- Renin-Angiotensin System Studies
- Advanced Electron Microscopy Techniques and Applications
- Acute Kidney Injury Research
- RNA and protein synthesis mechanisms
- Cell Adhesion Molecules Research
- Muscle and Compartmental Disorders
- Lipid Membrane Structure and Behavior
- Caveolin-1 and cellular processes
- RNA Research and Splicing
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Receptor Mechanisms and Signaling
- Advanced Proteomics Techniques and Applications
Niigata University
2024
Megalin (low-density lipoprotein receptor-related protein 2) is a giant glycoprotein of about 600 kDa, mediating the endocytosis more than 60 ligands, including those proteins, peptides, and drug compounds [S. Goto, M. Hosojima, H. Kabasawa, A. Saito, Int. J. Biochem. Cell Biol. 157 , 106393 (2023)]. It expressed predominantly in renal proximal tubule epithelial cells, as well brain, lungs, eyes, inner ear, thyroid gland, placenta. also known to mediate toxic compounds, particularly that...
Abstract Hemolysis‐induced acute kidney injury (AKI) is attributed to heme‐mediated proximal tubule epithelial cell (PTEC) and tubular cast formation due intratubular protein condensation. Megalin a multiligand endocytic receptor for proteins, peptides, drugs in PTECs mediates the uptake of free hemoglobin heme‐scavenging α 1 ‐microglobulin. However, understanding how megalin involved development hemolysis‐induced AKI remains elusive. Here, we investigated megalin‐related pathogenesis...
Background: Kidney angiotensin (Ang) II is produced mainly from liver-derived, glomerular-filtered angiotensinogen (AGT). Podocyte injury has been reported to increase the kidney Ang content and induce Na + retention depending on function of megalin, a proximal tubular endocytosis receptor. However, how megalin regulates renal action remains elusive. Methods: We used mass spectrometry-based, parallel reaction-monitoring assay quantitate in plasma, urine, homogenate kidney-specific...