A5101492962- Antimicrobial Peptides and Activities
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
- Chemical Synthesis and Analysis
- Orthopedic Infections and Treatments
- Nicotinic Acetylcholine Receptors Study
- Biochemical and Structural Characterization
Gwangju Institute of Science and Technology
2023-2024
Antimicrobial peptides (AMPs) are promising therapeutics in the fight against multidrug-resistant bacteria. As a mimic of AMPs, peptoids with N-substituted glycine backbone have been utilized for antimicrobials resistance proteolytic degradation. known to kill bacteria by membrane disruption; however, nonspecific aggregation intracellular contents is also suggested as an important bactericidal mechanism. Here,structure-activity relationship (SAR) library indole side chain-containing...
Antimicrobial peptides (AMPs) represent promising therapeutic modalities against multidrug-resistant bacterial infections. As a mimic of natural AMPs, peptidomimetic oligomers like peptoids (i.e., oligo-N-substituted glycines) have been utilized for antimicrobials with resistance proteolytic degradation. Here, we explore the conjugation catalytic metal-binding motifs─the amino terminal Cu(II) and Ni(II) binding (ATCUN) motif─with cationic amphipathic antimicrobial to enhance their efficacy....
Optical Diffraction Tomography Article number 2302483 by Seongsoo Lee, Jiwon Seo, and co-workers presents the first demonstration of optical diffraction tomography (ODT) being successfully applied to monitor bacterial phenotypical changes in a real-time label-free manner upon treatment antimicrobial peptides (AMPs) peptoids. ODT can be an established imaging technique for investigating mechanisms action various antimicrobials.