A5019479457- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Genomics and Phylogenetic Studies
- Vibrio bacteria research studies
- Medical Malpractice and Liability Issues
- Legal Education and Practice Innovations
- Legume Nitrogen Fixing Symbiosis
- Mesenchymal stem cell research
- HIV/AIDS Research and Interventions
- Invertebrate Immune Response Mechanisms
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Plant Pathogenic Bacteria Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Dispute Resolution and Class Actions
- Immune Cell Function and Interaction
- Kruppel-like factors research
Fudan University
2023-2025
State Key Laboratory of Genetic Engineering
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Hainan University
2018
Abstract Intestinal homeostasis relies on the continuous renewal of intestinal stem cells (ISCs), which could be epigenetically regulated. While protein arginine methyltransferase 5 (Prmt5) is known to play a key role in multiple organs as an epigenetic modifier, its specific function maintaining remains elucidated. Here, we show that Prmt5 highly expressed mouse crypts. The deletion results ISCs deficiency, ectopic localization Paneth cells, and spontaneous colitis. Mechanistically,...
Abstract Background Mesenchymal stem cell (MSC) therapy is an attractive treatment option for various cancers. Whether MSCs can be used to treat well-differentiated endometrial cancer (EC) remains unclear. The aim of this study explore the potential therapeutic effects on EC and underlying mechanisms. Methods adipose-derived (AD-MSCs), umbilical-cord-derived (UC-MSCs), endometrium-derived (eMSCs) malignant behaviors cells were explored via in vitro vivo experiments. Three models, including...
Bacterial β-galactosidase is involved in lactose metabolism and acts as a prevalent reporter enzyme used studying the activities of prokaryotic eukaryotic promoters. Xanthomonas campestris pv. (Xcc) pathogen black rot disease crucifers. β-Galactosidase activity can be detected Xcc culture, which makes Escherichia coli LacZ unable to Xcc. To systemically understand construct β-galactosidase-deficient strain for promoter analysis using reporter, we here analyzed putative β-galactosidases 8004....
Xanthomonas oryzae pv. (Xoo) is the causal agent of rice bacterial blight disease, which causes a reduction in production. The interaction between Xoo and model for study gene-for-gene hypothesis, resistance (R) gene encoding product interacts with an effector molecule encoded by corresponding avirulence (avr) gene. Rice XA21 functions as plant innate immune receptor (R protein) recognizes protein (RaxX) to induce response cope pathogen attack. sulphuration RaxX tyrosine sulphotransferase...
Medical disputes are a recurrent and pressing issue in hospitals, posing significant challenges to the functioning of medical institutions. We aimed investigate whether receiving rule law publicity on short video platforms is relevant preventing among healthcare professionals.We collected data from 37,978 professionals 130 tertiary public hospitals. Participants were classified into two groups according presence platforms. A subgroup analysis was performed before after propensity score...