A5103231043- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Whipple's Disease and Interleukins
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Sepsis Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Urticaria and Related Conditions
- S100 Proteins and Annexins
- Clusterin in disease pathology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
Inserm
2018-2023
Université d'Angers
2023
Nantes Université
2023
Centre National de la Recherche Scientifique
2023
Université de Rouen Normandie
2018-2020
Centre Hospitalier Universitaire de Rouen
2020
Rationale: Extracellular histones, released into the surrounding environment during extensive cell death, promote inflammation and these deleterious roles have been well documented in sepsis. Clusterin (CLU) is a ubiquitous extracellular protein that chaperones misfolded proteins promotes their removal. Objectives: We investigated whether CLU could protect against properties of histones. Methods: assessed histone expression patients with sepsis evaluated protective role histones vitro assays...
<h3>Background</h3> Tocilizumab (TCZ), a humanised monoclonal antibody directed against IL-6 receptor, is an efficient treatment for rheumatoid arthritis (RA) but its mechanisms of action are not yet well understood. <h3>Objectives</h3> To identify new TCZ, by the study gene expression fluctuations, between baseline (BL) and 3 months (T<sub>3m</sub>), in RA patients. <h3>Methods</h3> TOSCA has been realised to evaluate efficiency tolerance TCZ administrated subcutaneously active Among 125...