A5024914078- Immune cells in cancer
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- interferon and immune responses
- Eosinophilic Esophagitis
National Cheng Kung University
2021-2025
Background: Increased IL-6 level, M2 macrophages and PD-1+CD8+ T cells in tumor microenvironments (TME) have been identified to correlate with resistance checkpoint blockade immunotherapy, yet the mechanism remains poorly understood. Rab small GTPase-mediated trafficking of cytokines is critical immuno-modulation. We previously reported dysregulation Rab37 lung cancer cells, whereas roles tumor-infiltrating immune immunotherapy are unclear. Methods: The growth syngeneic mouse allograft wild...
Abstract IL-33 is a danger signal that binds to its receptor ST2L promote tumor progression. This study identifies the IL-33/ST2L positive-feedback loop and trafficking of membrane presentation in macrophages contribute lung Mechanistically, induces upregulation by activating NF-κB, which promoter region gene. Moreover, Rab37, small GTPase involved trafficking, mediates plasma M2 macrophages. IL-33/NF-κB/ST2L/Rab37 axis promotes loops enhance expression Notably, neutralizing antibodies...
Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger factor. Here, we demonstrate a new mechanism Kras mutation-driven transcriptional activation elucidate interplay between its upstream regulators downstream targets promoting neo-angiogenesis. Methods: Luciferase activity, RT-qPCR ChIP-qPCR assays were used to examine cell models. In vitro vivo conducted....