A5077184526- Sepsis Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
- Immune Response and Inflammation
- Mass Spectrometry Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Atomic and Molecular Physics
- Ion-surface interactions and analysis
- Neonatal and Maternal Infections
Fudan University
2019-2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Huashan Hospital
2024-2025
Institute of Modern Physics
2019
Despite its high mortality, specific and effective drugs for sepsis are lacking. Decoy receptor 3 (DcR3) is a potential biomarker the progression of inflammatory diseases. The recombinant human DcR3-Fc chimera protein (DcR3.Fc) suppresses responses in mice with sepsis, which critical improving survival. Fc region can exert detrimental effects on patient, endogenous peptides highly conducive to clinical application. However, mechanisms underlying DcR3 unknown. Herein, we aimed demonstrate...
Despite the high mortality rate associated with sepsis, no specific drugs are available. Decoy receptor 3 (DcR3) is now considered a valuable biomarker and therapeutic target for managing inflammatory conditions. DcR3-SUMO, an analog of DcR3, has simple production process yield. However, its precise underlying mechanisms in sepsis remain unclear. This study investigated protective effects DcR3-SUMO on lipopolysaccharide (LPS)-induced cells septic mice. We evaluated DcR3 intervention...
Objectives The present study was conducted to reappraise the prognostic value of decoy receptor 3 (DcR3) for patients with sepsis and septic shock according latest Sepsis-3 definitions. Methods Subjects suffering from or were enrolled within 6 h admission. Sequential Organ Failure Assessment (SOFA) score plasma levels DcR3, C-reactive protein, procalcitonin, interleukin-6 measured. Group comparisons made based on survival status day 28 after onset. Predictors mortality assessed using Cox...
Three-fragment dissociation dynamics of ${\mathrm{C}}_{2}{\mathrm{H}}_{2}{}^{2+}$ dications and ${\mathrm{C}}_{2}{\mathrm{H}}_{2}{}^{3+}$ trications induced by electron capture slow (3-keV/u) ${\mathrm{Ar}}^{8+}$ ions are investigated. Using cold target recoil ion momentum spectroscopy, the complete kinematic information thus kinetic energy releases determined for three-fragment channels,...