A5032782896- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Cardiovascular Function and Risk Factors
- Pharmacological Effects of Natural Compounds
- Tribology and Wear Analysis
- Medicinal Plants and Bioactive Compounds
- Metal and Thin Film Mechanics
- Flavonoids in Medical Research
- Saffron Plant Research Studies
- Traditional Chinese Medicine Analysis
- High Entropy Alloys Studies
- Surface Treatment and Residual Stress
- Coal Combustion and Slurry Processing
- Gastrointestinal motility and disorders
- Hearing Loss and Rehabilitation
- Medicinal Plants and Neuroprotection
- Belt Conveyor Systems Engineering
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Neuroscience and Music Perception
- Congenital Ear and Nasal Anomalies
- Plant Disease Management Techniques
- DNA Repair Mechanisms
Seventh People's Hospital of Shanghai
2023-2024
Zhejiang University
2021-2023
State Key Laboratory of Food Science and Technology
2022-2023
Nanchang University
2022-2023
Peking University First Hospital
2022-2023
Peking University
2022-2023
Beijing National Laboratory for Molecular Sciences
2022
Mudanjiang Medical University
2021
Yanshan University
2014-2017
Ruijin Hospital
2016
Abstract Polysaccharides are typically resistant to digestion in the gastrointestinal tract and instead degraded by gut microbiota colon. As such, they commonly employed as carriers for colon‐targeted drugs, with potential regulate microbiota. Pectin, carrageenan, guar gum, xanthan gum used polysaccharide carriers, but their degradation under colitis conditions well effects on remains unclear. In this study, we performed vitro fermentation of these four polysaccharides using colonic content...
Alzheimer's disease (AD) is a common degenerative brain disorder with limited therapeutic options. Curcumin (Cur) exhibits neuroprotective function in many diseases. We aimed to explore the role and mechanism of Cur AD. Firstly, we established AD mice by injecting amyloid-β1-42 (Aβ1–42) solution into hippocampus. Then, received 150 mg/kg/d for 10 consecutive days. The Morris water maze test was conducted evaluate cognitive hidden platform training probe trials. To assess spatial memory mice,...
Abstract Background Crocin has a good prospect in the treatment of Alzheimer's disease (AD), but mechanisms underlying its neuroprotective effects remain elusive. This study aimed to investigate and AD. Methods AD mice were set up by injecting Aβ 25‐35 solution into hippocampus. Then, injected intraperitoneally with 40 mg/kg/day for 14 days. Following completion treatment, an open‐field test, Y‐maze test Morris water maze conducted evaluate impact on spatial learning memory deficiency mice....
Alzheimer's disease (AD) is the most common form of dementia, and ginsenoside Rg2 (Rg2) proven to inhibit AD's progression. This study investigates potential benefits treatment on 3xTg-AD mice. Following 6 weeks gavage treatment, Rg2-treated mice exhibited improved spatial recognition memory behaviors, regional cerebral blood flow, histopathological injury hippocampus, which were observed through a Y-maze test, laser Doppler flowmetry, hematoxylin-eosin staining. Additionally, caused...
Abstract Background Left ventricular hypertrophy (LVH) is an independent prognostic factor for cardiovascular events and it can be detected by echocardiography in the early stage. In this study, we aim to develop a semi-automatic diagnostic network based on deep learning algorithms detect LVH. Methods We retrospectively collected 1610 transthoracic echocardiograms, included 724 patients [189 hypertensive heart disease (HHD), 218 hypertrophic cardiomyopathy (HCM), 58 cardiac amyloidosis (CA),...
Abstract The occurrence and development of insulin resistance (IR) are usually related to the change gut microbiota. Our previous study showed that arabinogalactan (AG) could selectively increase relative abundance Bifidobacterium longum Faecalibacterium prausnitzii in vitro fermentation. However, their effect on IR remains unclear. In current study, we investigated effects AG, B. longum, F. combinations insulin‐resistant mice. Intake AG those two strains reduced body weight, fat...
The Chinese medicinal herb Scutellaria barbata D. Don has antitumour effects and is used to treat liver cancer in the clinic. S. polysaccharide (SBP), one of main active components extracted from Don, exhibits activity. However, there still a lack research on extraction optimization, structural characterization, anti-hepatoma activity acidic polysaccharides Don. In this study, optimal conditions for SBP were determined by response surface methodology (RSM): material-liquid ratio was 1:25,...
Periplogenin is a compound extracted from cortex periplocae. In the monomers' screening for inhibiting nasopharyngeal carcinoma, we found that periplogenin can inhibit carcinoma; however, its mechanism still unclear. this study, chemical structure of was uploaded to PubChem database in order obtain target periplogenin. The NPC's differential genes were obtained by analyzing carcinoma data GEO R software. common and through Cytoscape. Through software analysis, ALB, epidermal growth factor...
Abstract The paper g describes a model meant for analysis of the wear geometry plain woven fabric composites. referred consists mathematical description based on Peirce’s coupled with stratified method solution geometry. evolutions area ratio weft yarn, warp yarn and matrix resin worn surface are simulated by MatLab software in combination diameters, yarn-to-yarn distances, structure phases (SPs). By comparing theoretical experimental results from PTFE/Kevlar experiment, it can be concluded...
Auditory change detection is a pre-attentive cortical auditory processing ability. Many neurological and psychological disorders can lead to defects in this process. Some studies have shown that phase synchronization may be related discrimination. However, the specific contributions of at different frequencies remain unclear.We analyzed electroencephalogram (EEG) data 29 healthy adults using an oddball paradigm consisting standard stimulus five deviant stimuli with varying frequency...
Abstract Background Ultrasonic echocardiography is commonly used for monitoring myocardial dysfunction. However, it has limitations such as poor quality of images and subjective judgment doctors. Methods In this paper, a calculation model based on optical flow tracking echocardiogram proposed the quantitative estimation motion segmental wall. To improve accuracy estimation, method confidence-optimized multiresolution(COM) to reduce errors caused by large amplitude presence “shadows” other...
Abstract Purpose To describe a novel DNA2 variant contributing to defects in mtDNA maintenance and depletion syndrome (MDS), the clinical histological findings associated with this variation. Methods Herein, we case of patient who presented hearing loss myopathy, given family history similar father, was evaluated by sequencing deafness gene panel, mitochondrial genome, exome. Furthermore, tissue staining, copy number detection, sequencing, long-range polymerase chain reaction tests were also...
ICU is the important place of ventilator associated pneumonia, occurrence fatality rate in patients with pneumonia higher. In this paper, cause and nursing research progress are summarized, that enhance their awareness importance care use normative evidence- based clinical practice thinking process, explore methods more appropriate, to reduce incidence great help. Key words: Nursing care; Pneumonia, ventilator-associated; Intensive units; Progress
Abstract Background The above experimental results show that SBP-2A isolated and purified from Scutellaria barbata may be a candidate drug for further evaluation in cancer prevention, which provides clue studies on the molecular mechanism of its anticancer activity against human liver cells. Methods crude polysaccharide (SBP) was extracted with water precipitated alcohol. Optimal extraction conditions were determined by response surface methodology: solid-liquid ratio 1:25, time 2 h,...