A5053151830- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Respiratory viral infections research
- PI3K/AKT/mTOR signaling in cancer
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 detection and testing
- Oral Health Pathology and Treatment
- Oral health in cancer treatment
- Muscle metabolism and nutrition
National Yang Ming Chiao Tung University
2023-2025
Cisplatin resistance poses a major challenge in the treatment of oral squamous cell carcinoma (OSCC). Deeper investigations into mechanisms underlying this drug is great importance. Here, we used cellular assays and clinical immunohistochemistry to examine molecular pathways involved both innate acquired cisplatin resistance. We demonstrated that p62-mTORC1 signaling complex plays pivotal role, driven by EGFR network, specifically through PI3K-Akt axis transcription factor C/EBP-β. Elevated...
ABSTRACT Background The oral microbiome has been shown to be associated with the development of squamous cell carcinoma (OSCC). Research primarily focused on elucidating oncogenic mechanisms specific pathogens by comparing microbiomes OSCC and normal tissues. However, characteristics in precancerous state remain less understood, as does influence metabolic environmental factors OSCC‐associated microbiomes. Methods In this study, we analyzed mucosa‐associated normal, precancerous, lesions...
The entry of SARS-CoV-2 into host cells involves the interaction between viral spike protein and human angiotensin-converting enzyme 2 (ACE2) receptor. Given that evolves rapidly to evade immunity, therapeutics block ACE2 accessibility, such as decoys, could serve an alternative strategy for attenuating infection. Here, we constructed a drug screening platform based on oral epithelial identify peptides or compounds capable blocking spike-ACE2 interaction. We engineered short decoy peptides,...