A5016759615- Tissue Engineering and Regenerative Medicine
- Lattice Boltzmann Simulation Studies
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Circulatory Support Devices
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Muscle activation and electromyography studies
- Aerosol Filtration and Electrostatic Precipitation
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Muscle Physiology and Disorders
- Inhalation and Respiratory Drug Delivery
- Cardiac Ischemia and Reperfusion
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
Carnegie Mellon University
2024
Adarza BioSystems (United States)
2020-2021
Therapeutic development for skeletal muscle diseases is challenged by a lack of ex vivo models that recapitulate human physiology. Here, we engineered 3D tissue in the Biowire II platform could be maintained and electrically stimulated long-term. Increasing differentiation time enhanced myotube formation, modulated myogenic gene expression, increased twitch tetanic forces. When mimicked exercise training applying chronic electrical stimulation, "exercised" tissues showed size contractility...
Abstract The role of C‐type natriuretic peptide (CNP) in the regulation cardiac function humans remains to be established as previous investigations have been confined animal model systems. Here, we used well‐characterized engineered tissues (ECTs) generated from human stem cell‐derived cardiomyocytes and fibroblasts study acute effects CNP on contractility. Application elicited a positive inotropic response evidenced by increases maximum twitch amplitude, contraction slope calcium...
The hollow fiber membrane bundle is the functional component of artificial lungs, transferring oxygen and carbon dioxide to from blood. It also primary location blood clot formation propagation in these devices. geometric design bundles defined by a narrow range parameters that determine gas exchange efficiency flow resistance, such as packing density, path length, frontal area. However, affect thrombosis. This study investigated effect on using 3-D printed chambers mimic geometry patterns...
Abstract The hollow fiber membrane bundle is the functional component of artificial lungs, transferring oxygen to and carbon dioxide from blood. It also primary location blood clot formation propagation in these devices. geometric design bundles defined by a narrow set parameters that determine gas exchange efficiency flow resistance, principally: packing density, path length, frontal area. These same affect thrombosis. This study investigated effect on using 3D printed chambers mimic...
The anthracycline doxorubicin is an effective anti-tumor agent widely used in both adults and children. One major adverse effect of therapy dose-dependent cardiotoxicity, ranging from asymptomatic reduction left ventricular ejection fraction to more serious, potentially fatal symptoms including arrythmias congestive heart failure. exact mechanism doxorubicin-induced cardiotoxicity remains unknown. Recently, human induced pluripotent stem cells (hiPSC) have emerged as a potential tool model...