A5110948396- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Pain Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Pharmacology and Obesity Treatment
- Natural Antidiabetic Agents Studies
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- Berberine and alkaloids research
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Cholinesterase and Neurodegenerative Diseases
- Antifungal resistance and susceptibility
- Biochemical effects in animals
- Botulinum Toxin and Related Neurological Disorders
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Alzheimer's disease research and treatments
- Diabetes Treatment and Management
- Computational Drug Discovery Methods
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Curcumin's Biomedical Applications
University of Miami
2025
Post Graduate Institute of Medical Education and Research
2015-2024
Institute of Post Graduate Medical Education and Research
2021
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
2014
West Bengal University of Animal and Fishery Sciences
2014
Block Engineering (United States)
2013
Indira Gandhi Medical College
1997-2001
Marymount University
1976
Christian Medical College & Hospital
1974-1976
Christian Medical College
1976
Abstract Aims To compare the efficacy and safety of pregabalin amitriptyline in alleviating pain associated with diabetic peripheral neuropathy. Methods A randomized, double‐blind, crossover, active–control, clinical trial variable dose titration was carried out ( n = 51). Amitriptyline orally, at doses 10, 25 50 mg night‐time 75, 150 300 twice daily, by optional used. Each drug treatment 5 weeks. There a placebo washout period for 3 weeks between two drugs. Assessment relief, overall...
To compare the efficacy and safety of duloxetine amitriptyline in painful diabetic neuropathy (PDN).In this randomized, double-blind, cross-over, active-control trial, 58 patients received orally once daily at bedtime, each for 6 weeks with optional dose uptitration fortnightly. Single-blinded placebo washout was given 2 between two treatments a single-blinded run-out phase 4 end treatment period. Pain relief measured by patient's global assessment efficacy, using visual analog scale (0-100)...
Acinetobacter baumannii, a non-motile, glucose non fermentative, oxidase negative, encapsulated, gram-negative coccobacillus, has recently gained importance because of its increasing resistance to the available antibiotics. Three main mechanisms in A. baumannii are: enzymes inactivating antibiotics, reduced entry into target site bacteria and alteration or cellular functions due mutations. Multi-drug resistant Baumannii, including carbapenam are posing potential threat mankind by causing...
Abstract The present study was planned to evaluate the role of curcumin in formalin‐induced orofacial pain rats that mimics typical human pain. Adult Wistar either sex received an injection 50 µL 5% v/v subcutaneous formalin into one vibrissal pad and consequent facial grooming behavior monitored. Animals exhibited two distinct periods nocifensive grooming: (a) acute phase lasting 0–6 min; (b) a tonic 6–45 min. analgesic response observed at doses 25, 50, 100, 200, 400 600 mg/kg i.p.,...
Proton pump inhibitors, by elevating plasma gastrin, can influence glucose-insulin homeostasis. Because there are no controlled clinical trials, the present study was planned to evaluate effect of pantoprazole, a proton inhibitor, on homeostasis in patients with type 2 diabetes (T2DM). In this 12-wk, randomized, double-blind, placebo-controlled study, T2DM were allocated either pantoprazole or placebo treatment an equal ratio. Alterations glycosylated hemoglobin (HbA1c), fasting glucose,...
Studies in the animals suggested that Peroxisome proliferators activated receptors (PPARs) may be involved seizure control and selective agonists of PPAR α or γ raise thresholds. The present study was contemplated with aim evaluating anti kindling effects mechanism bezafibrate, a proliferator-activated (PPAR-α) agonist pentylenetetrazole (PTZ) induced model seizures rats.In PTZ kindled Wistar rat model, different doses bezafibrate (100 mg/kg, 200 mg/kg 300 mg/kg) were administered...
The role of nuclear factor-2 erythroid related (Nrf2) activator, berberine (BBR), has been established in rat model streptozotocin induced diabetic neuropathy. Around 30-40% cancer patients, on paclitaxel (PTX) chemotherapy develop peripheral present study was contemplated with the aim establishing neuropathy preventive BBR, rats.A total 30 Wistar rats were divided into five groups as follows: Group I: dimethyl sulfoxide; II: PTX+ 0.9% NaCl; III: Amitriptyline (ATL) + PTX; IV: BBR (10 mg/kg)...
Berberine (BBR) is derived from the Berberis species and has demonstrated beneficial effects in various neurodegenerative disorders animal models. The objective of this study was to evaluate antiepileptic, antioxidative, anti-apoptotic BBR a pentylenetetrazole (PTZ)-induced kindling model epilepsy rats.A total 30 male Wistar rats were randomly assigned receive (100 mg/kg, oral), sodium valproate (200 i.p.), or saline (0.9% NaCl, i.p.) followed by PTZ (35 on alternate days until developed for...
The possible neuroprotective effect of progesterone, a steroid hormone, on acute phase changes in mouse model cerebral ischaemia induced by bilateral common carotid artery occlusion (BCAO) was studied. A total 72 male mice were included the study. BCAO used to induce partial global ischaemia. Morphological assessment measurement infarct size and brain oedema. Post-ischaemic seizure susceptibility assessed using subconvulsive dose pentylenetetrazole (30 mgkg(-1) i.p.). Biochemical estimations...
Fifty-four patients with diabetic peripheral neuropathy were treated carbamazepine for a period of one year. Clinical assessment and nerve conduction velocity studies (NCV) done periodically. Forty-nine had symptomatic relief all sensory manifestations but NCV remained essentially unchanged. Untoward effects the drug frequent transitory. It was concluded that is dependable treatment polyneuropathy.
Background: The primary cause of death in chronic kidney disease (CKD) is cardiovascular disease. Life’s Essential 8 (LE8) an established measure health. Our objective was to examine the relationship between health (LE8 score) and CKD progression among Hispanic/Latino adults, understudied but growing population. Methods: Hispanic Community Health Study/Study Latinos (HCHS/SOL) a longitudinal cohort adults aged 18-74 years from four cities United States, examined at visit 1 (V1, 2008-2011) 2...