About
Contact & Profiles
A5103081405
Research Areas
- Pluripotent Stem Cells Research
- Nuclear Structure and Function
- RNA Interference and Gene Delivery
Indian Institute of Technology Bombay
2024
Abstract Embryonic stem cells (ESCs) which are susceptible to DNA damage depend on a robust and highly efficient response (DDR) mechanism for their survival. However, the implications of physical force-mediated ESC fate remains unclear. We show that stiffness-dependent spreading mouse ESCs (mESCs) induces through nuclear compression, with causing differentiation early induction Lamin A/C expression. Interestingly, is associated rescue activation DDR factor ATR. While ATR typically known play...
10.1101/2024.03.15.585216
preprint
EN
bioRxiv (Cold Spring Harbor Laboratory)
2024-03-17
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