A5000934662- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Microbial Natural Products and Biosynthesis
- Quinazolinone synthesis and applications
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Plant biochemistry and biosynthesis
- Steroid Chemistry and Biochemistry
- Plant and fungal interactions
- Nanoparticle-Based Drug Delivery
- Cholesterol and Lipid Metabolism
Kitasato University
2019-2024
complex (MAC) is a serious disease that mainly caused by infection with the non-tuberculous mycobacteria (NTM),
Mycobacterium avium complex (MAC) is a serious disease mainly caused by M. and M.intracellulare. Although the incidence of MAC infection increasing worldwide, only few agents are clinically used, their therapeutic effects limited. Therefore, new anti-MAC needed. Approximately 6600 microbial samples were screened for anti-mycobacterial that inhibit growth both intracellulare, two culture broths derived from marine actinomycete strains OPMA1245 OPMA1730 had strong activity. Nosiheptide (1) was...
Among four mycobacteria, Mycobacterium avium, M. intracellulare, bovis BCG and Mycobacteroides (My.) abscessus, we established a silkworm infection assay with My. abscessus. When silkworms (fifth-instar larvae, n = 5) were infected through the hemolymph abscessus (7.5 × 107 CFU/larva) bred at 37 °C, they all died around 40 h after injection. Under conditions, clarithromycin amikacin, clinically used antimicrobial agents, exhibited therapeutic effects in dose-dependent manner. Furthermore,...
Recently, liposomal formulations that target macrophages have been used to treat lung diseases. However, the detailed mechanism of cellular uptake must be elucidated identify a formulation with excellent efficiency non-tuberculous mycobacterial disease. We studied effect lipid composition on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)/cholesterol (Chol) liposomes size approximately 200 nm into THP-1-derived macrophages. The amount DPPC/Chol (80/20 mol%) was greater than (60/40 and...
Abstract. Ali A, Passitta M, Rante H, Wahyudin E, Djide NJN, Politan RJ, Nur EA, Shigeno S, Ohte Kobayashi K, Hosoda Tomoda Ohshiro T. 2024. Antibiotic production by an endophytic Streptomyces isolated from the medicinal plant Poikilospermum suaveolens. Biodiversitas 25: 2221-2229. This study investigates antibiotic potential of actinomycetes suaveolens plants. Samples were collected various parts in karst ecosystems. Endophytic cultured and screened for antimicrobial activity using agar...