A5019934183- Neurobiology and Insect Physiology Research
- Insect and Pesticide Research
- Retinal Development and Disorders
- Synthesis and Catalytic Reactions
- Pluripotent Stem Cells Research
- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Mosquito-borne diseases and control
- Antimicrobial agents and applications
Nanjing Medical University
2024
Jilin University
2024
Currently, the Cas9 and Cas12a systems are widely used for genome editing, but their ability to precisely generate large chromosome fragment deletions is limited. Type I-E CRISPR mediates broad unidirectional DNA degradation, controlling size of Cas3-mediated has proven elusive thus far. Here, we demonstrate that endonuclease deactivation (dCas9) can control large-fragment in mammalian cells. In addition, report elimination Y precise retention Sry gene mice using CRISPR/Cas3 dCas9-controlled...
Abstract Mosquitoes within the Culex pipiens complex play a crucial role in human disease transmission. Insecticides, especially pyrethroids, are used to control these vectors. Mosquito legs main entry point and barrier for insecticides gain their neuronal targets. However, resistance mechanism mosquito is unclear. Herein, we employed transcriptomic analyses isobaric tags relative absolute quantitation techniques investigate mechanism, focusing on Cx. legs. We discovered 2346 differentially...
Mosquitoes within the