SUMMARY A total of 142 patients (84 per cent aged less than 20 years) with various forms generalized epilepsy have been treated sodium valproate alone or in combination other drugs. The mean duration symptoms was six years, and half the had daily seizures. Nine typical absences, 33 absences automatisms, 28 tonic‐clonic seizures without photosensitivity, 72 myoclonic epilepsy. Dosage varied from 23 to 54mg/kg twice‐daily administration usual. Estimation serum levels did not assist management....

Summary: Male patients receiving antiepileptic drugs (AEDs) have often complained of hyposexuality. Few studies been done on semen analysis, which is relevant for assessment potential and possible reproductive outcome in such cases. We evaluated the effect epilepsy itself and/or phenytoin (PHT) male system. Fifty‐five with (42 PHT 13 untreated) 28 healthy normal controls were studied by analysis. Serum samples from 21 55 also analyzed testosterone, luteinizing hormone (LH),...

Context: Previous studies suggestthe effect of metformin on TSH levels, but its impacton free T4 (fT4) levels has not been understood clearly. Objective:This Meta-analysis aims to studythe effects serum-free T4(fT4) in patients with or without underlying thyroid disease and/or diabetes. Data Sources:We reviewed articles from the Cochrane Library based systematic protocol. Extraction: Demographic, clinical, and relevant data was extracted. were analyzed according changes fT4 administration....

Objectives - To study the usefulness of short-term recording video electroencephalography (VEEG) as an outpatient procedure with placebo induction (PLIN) and intravenous saline in cases pseudoseizures (Psz). Material methods Fifty suspected Psz were enrolled. They divided into 2 groups: Group 1 consisted patients frank Psz, those where diagnosis was uncertain. VEEG done 10 ml used for placebo-induction. Results Of 50 patients, 24 (48%) 26 (52%) 2. Fifteen (30%) had a spontaneous event during...

The recognition of photosensitivity depends upon the finding an abnormal EEG response to intermittent photic stimulation (IPS). Photosensitive epilepsy being most common form reflex epilepsy, has been studied extensively and is reported account for 5-10% epileptic population in general. One thousand unselected epileptics hailing from different parts Northern India were screened photosensitivity, both clinically on a standard protocol IPS-provoked recordings. Six patients (mean age 14.5 +/-...

The clinical data on individuals who were diagnosed to have juvenile myoclonic epilepsy (JME) the basis of jerks alone has been analysed. points in favour and against with only being classified as "affected" for research JME are discussed.We studied 15 persons a series 161 patients their relatives. Detailed information seizure types family members was collected. All affected examined by one person had at least conventional scalp EEG. CT/MRI brain done when indicated.Nine these probands while...

Thirty-nine children, seen between 1960 and 1973, showed suppression-burst activity in their original EEG recordings. Follow-up information was available for 19 girls 10 boys. Suppression-burst at a mean age of 4 months. Most the children (86 per cent) had infantile spasms, 96 cent were severely retarded on presentation. Fifteen died (52 cent), 9 them before 2, all severe retardation neurological abnormalities. Of 14 survivors, only 1 attends normal school (she mildly presentation), 71 are...

Objectives - Juvenile myoclonic epilepsy (JME) is a common, age related, idiopathic generalized epileptic syndrome. We aimed to define the expression of JME in Indian probands and study occurrence seizures/ syndromes their family members. Methods studied 225 with uniform protocol, recording type frequency seizures, precipitating factors, EEG data, history. Detailed pedigrees were drawn include all 1st- 2nd-degree relatives probands. The seizures/epileptic examined classified way. Results...

Summary: Purpose: To define the clinical features of syndrome seizures associated with single, small, enhancing computed tomography (CT) lesions (SSELs) in 235 Indian probands and seizure types among their family members. Human leukocyte antigen (HLA) class II genomic typing randomly selected 41 was done to identify role hereditary factors this syndrome. Methods: The probands, outcome, members were studied. Family data collected on relatives 212 additional neurologic diseases other than...

Large numbers of families with many members having seizures have been used to understand the role hereditary factors in pathogenesis human epileptic syndromes. We aimed establish a genetic database form hypothesis on possible contributions different syndromes.The occurrence and patterns epilepsies syndromes 1,219 Indian probands their relatives were studied. The concordance between was also analyzed.Of probands, 231 (19% 1219) had first- or second-degree affected seizures. Incidence family...

We report 8 additional cases of Joseph9s disease (JD) from India and conclude (1) the most common pattern is type III, with few types II II-III; (b) III JD in has an earlier onset symptoms (mean age at onset, 25.6 years) than Azorean cases; (3) a "pinched face" frequent minor clinical sign.

A case of peripheral neuropathy due to styrene is described. The diagnosis was confirmed by a motor-nerve conduction study and sural nerve biopsy.

Allergic rhinitis (AR) is an atopic disorder that affects the quality of life patients. AR symptoms include sneezing, nasal congestion, and mucus discharge. It often associated with several other eye-, ear-, nose-related along fatigue mood changes. The allergic reaction triggered by allergen. An understanding allergens affect a patient important for allergen avoidance, ultimately, treatment AR. This study aimed to identify common affecting patients A total 52 were identified this study. was...

Cerebrospinal fluid concentration of 5-hydroxyindolacetic acid (5-HIAA) was determined in 15 patients soon after recovery from status epilepticus. Similarly, with generalised epilepsy and persons without epilepsy, serving as controls, were also studied. The level 5-HIAA significantly reduced all epileptic or epilepticus, compared the nonepileptic control group. However, there no statistical difference between epilepticus those epilepsy. Among low levels CSF could not be correlated frequency...

Therapy with anticonvulsant drugs has often been found to result in somatic chromosome aberrations adult patients. There is also the possibility of epileptic fathers or mothers playing a role production congenital malformations their offspring. We have used technique sister chromatid exchange (SCE), sensitive indicator mutagenicity, observe mutagenic susceptibility both male and female patients different age groups prior after therapy, respect control. The frequency SCE was significantly...

Objectives– Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by expansion of GAA repeats in the frataxin gene. We have carried out first molecular analysis at locus Indian population. Materials and methods– Three families clinically diagnosed for were analyzed FRDA locus. The distribution was also estimated normal individuals origin. Results– All patients found to be homozygous repeat expansion. population show a bimodal with 94% alleles ranging from...