A5065829994- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- Metabolism and Genetic Disorders
- Ophthalmology and Visual Impairment Studies
- Neurological diseases and metabolism
- Retinal Imaging and Analysis
- Prion Diseases and Protein Misfolding
- Coral and Marine Ecosystems Studies
- Laser Applications in Dentistry and Medicine
- Remote Sensing in Agriculture
- Plant and animal studies
- Remote-Sensing Image Classification
- Diet and metabolism studies
- Retinal Development and Disorders
- Isotope Analysis in Ecology
- Retinal and Optic Conditions
- Trace Elements in Health
- Alzheimer's disease research and treatments
- Urticaria and Related Conditions
- Transcranial Magnetic Stimulation Studies
- Species Distribution and Climate Change
Agostino Gemelli University Polyclinic
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Istituto Universitario di Studi Superiori di Pavia
2023
Structure et Instabilité des Génomes
2019
Centre National de la Recherche Scientifique
2019
PatriNat
2019
University of Padua
2008-2015
We report the initial results from a phase I clinical trial for ALS. transplanted GMP-grade, fetal human neural stem cells natural in utero death (hNSCs) into anterior horns of spinal cord to test safety both and neurosurgical procedures these patients. The was approved by Istituto Superiore di Sanità competent Ethics Committees monitored an external Safety Board. Six non-ambulatory patients were treated. Three them received 3 unilateral hNSCs microinjections lumbar tract, while remaining...
Several studies have reported an increase in ALS incidence recent years but population-based Europe do not confirm this trend. To analyze over time we conducted a retrospective study the Padova district of Italy (1992 to 2005). We had previously survey same area 1980-1991.We used archives all neurological wards identify subjects with discharge diagnosis or motor neuron disease and resident district.We ascertained 182 patients (85 males 97 females; male:female ratio 0.88:1) 14-year period....
A new amyotrophic lateral sclerosis (ALS) category named 'UMN-dominant ALS' and defined as 'due predominantly to UMN signs but with minor electromyogram (EMG) denervation or LMN on examination' has been proposed. The clinical laboratory features of 20 patients UMN-dominant ALS are described here, their disease course is analysed longitudinally according disability progression, all these parameters compared those typical patients. Ten women 10 men diagnosed were evaluated. Their mean age at...
TAR DNA binding protein (TDP-43) is the pathologic substrate of neuronal and glial aggregates in amyotrophic lateral sclerosis (ALS). Pathologic TDP-43 hyperphosphorylated cleaved to generate abnormal species that accumulate cytoplasm. To assess hypothesis pathology as a systemic disorder ALS we analysed immunohistochemical biochemical profile muscle biopsies 30 patients controls. In all observed was constantly present an intranuclear localization Western blotting showed only 43-KDa band Our...
In this work, our aim is to report the functional outcomes of cataract surgery with smaller-incision new-generation miniature telescope (SING IMT) implantation followed by rehabilitation training in patients central visual loss due late-stage age-related macular degeneration (AMD). This retrospective study included who were monocularly implanted SING IMT and then a program based on 6 biweekly sessions focused abilities, reading, writing, motor integration mobility. A total 11 participants...
Owing to the frequent observation of poverty movements, facial hypomimia and balance impairment, amyotrophic lateral sclerosis (ALS) variant with predominance upper motor neuron involvement (UMN-ALS) is prone be diagnosed Parkinsonism. A clinical assessment, including velocity-dependent stretch response test differentiate between pyramidal extrapyramidal stiffness; Unified Parkinson's Disease Rating Scale Berg Balance assess degree bradykinesia postural instability; 123I-FP-CIT scintigraphy...
Some authors have recently reported that the CC genotype of single-nucleotide polymorphism (SNP) rs1541160 mapping within kinesin-associated protein 3 (KIFAP3) gene is associated with increased survival in sporadic amyotrophic lateral sclerosis (sALS).The relationship between and several clinical features 228 ALS patients was evaluated intent assessing any association phenotype KIFAP3. The SNP KIFAP3 expression profile investigated using real-time PCR a group 6 harboring 12 TT...
The distinction between primary lateral sclerosis (PLS) and amyotrophic (ALS) still remains debated. Recently, PLS patients displaying lower motor neuron (LMN) signs have been defined as ‘upper (UMN)-dominant ALS’, using ‘clinically pure PLS’ diagnosis to those with no LMN signs. To further characterize the involvement in UMN-dominant ALS we investigated presence extent of neurogenic abnormalities skeletal muscle affected a pyramidal syndrome consistent ALS. A total nine were analysed. In...
Abstract Imaging spectroscopy is a powerful tool used to support diverse Earth science and applications objectives, ranging from understanding mitigating widespread impacts of climate change management water at farm‐scale. Community studies, such as those deployed by NASA's Surface Biology Geology ESA's Copernicus Hyperspectral Mission for the Environment, have offered new tangible insights into user needs that are then incorporated overall mission planning design. These technologies tools...
SIGNIFICANCE This multicenter study assessed clinical and psychological aspects of infantile nystagmus syndrome (INS) focusing on its management nonsurgical treatment. PURPOSE aimed to assess features, management, relationship life, impact in a group patients with onset pediatric age. METHODS observational included diagnosed INS referred two Italian centers from January 1, 2017, December 31, 2020. Ophthalmologic orthoptic features visual function quality according nystagmus-specific life...
Abstract Background. Primary mitochondrial myopathies (PMM) are disorders that involve defects in oxidative phosphorylation (OXPHOS) and impair mainly, but not exclusively, skeletal muscles. Progressive external ophthalmoplegia (PEO), eyelid ptosis, exercise intolerance muscle weakness the most common symptoms of myopathy diseases, impairing ocular motility visual abilities. Methods. Twenty-five patients underwent complete ophthalmological examination, including best corrected acuity (BCVA),...
OBJECTIVE: We wished to verify if mitochondrial respiratory chain (RC) dysfunction, decreased SOD1, and elevated UCP3 expression occur in muscles of patients with sporadic hereditary ALS.