A5058439191- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Protein Degradation and Inhibitors
- Cardiovascular Issues in Pregnancy
- 3D Printing in Biomedical Research
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Protein Kinase Regulation and GTPase Signaling
The Ohio State University
2023-2025
The Ohio State University Wexner Medical Center
2024
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability to thrive progress in challenging tumor microenvironment. Dysregulation of the onco-suppressor miR-15a has been extensively documented PDAC. Here, we identified transcription factor Fos-related antigen-2 (Fra-2) as target mediating adaptive mechanism...
Abstract Liposarcoma, a rare malignancy originating from adipose tissue, includes well-differentiated liposarcoma (WDLPS) and dedifferentiated (DDLPS). While WDLPS exhibits indolent behavior, DDLPS is more aggressive, high-grade subtype, with nearly 85% local recurrence rate, exceptionally high compared to other tumors, 10-year survival rate of only 10%. No reliable biomarkers currently predict prognosis or recurrence. Current treatment relies primarily on radical surgery, often combined...
Background: Dedifferentiated liposarcoma is a formidable sarcoma subtype due to its high local recurrence rate and resistance medical treatment. While 2D cell cultures are still commonly used, 3D culture systems have emerged as promising alternative, particularly scaffold-based techniques that enable the creation of models with more accurate cell-stroma interactions. Objective: To investigate how structures or without scaffold existence would affect lines growth morphologically biologically....
Abstract Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes soft tissue sarcoma (STS). Complete surgical resection remains mainstay treatment while high rate locoregional recurrence constitutes predominant cause mortality. Well- differentiated (WDLPS) and dedifferentiated (DDLPS) are frequent RPLPS present amplified MDM2 gene as a hallmark. However, there few reports evaluating role alternatively spliced transcripts in RPLPS. In this study, we assessed...
To determine the utility of using total peripheral systemic vascular resistance assessed non-invasive cardiac monitor for individualizing duration postpartum magnesium sulfate in individuals with preeclampsia severe features. Single center pilot randomized controlled trial which singleton pregnant features were to 24 h per standard care (control group) or individualized based on reduction post-delivery (intervention group). Systemic was monitoring Cheetah® system. A 30 % (maintained 1 h)...
Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes soft tissue sarcoma (STS). Complete surgical resection remains mainstay treatment, while high rate locoregional recurrence constitutes predominant cause mortality. Well-differentiated (WDLPS) and dedifferentiated (DDLPS) are frequent RPLPS present amplified MDM2 gene as a hallmark. However, there few reports evaluating role alternatively spliced transcripts in RPLPS. In this study, we assessed MDM2-ALT2...