A5102728089- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Advanced Nanomaterials in Catalysis
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Biosensors and Analytical Detection
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Wound Healing and Treatments
- RNA and protein synthesis mechanisms
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Nanoparticles: synthesis and applications
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Chemotherapy-induced organ toxicity mitigation
- Viral Infectious Diseases and Gene Expression in Insects
- Autophagy in Disease and Therapy
Guangxi Medical University
2019-2025
Nanjing Drum Tower Hospital
2024
Theranostics (New Zealand)
2021-2024
Southwest University
2024
Nanjing Medical University
2024
Nanjing University
2024
Xihua University
2023
Chinese Academy of Sciences
2012
International Centre for Materials Physics
2012
It is an exigent need for the development of hydrogel dressings with desirable injectability, good adhesive, antibacterial, and wound healing promotion properties. Herein, multifunctional injectable hydrogels tissue adhesion are designed based on Ag-doped Mo2C-derived polyoxometalate (AgPOM) nanoparticles, urea, gelatin, tea polyphenols (TPs) antibacterial acceleration. After being injected into tissue, urea diffuses out under concentration gradient, TPs gelatin chains recombine to trigger...
Traditional tumor treatments have the drawback of harming both cells and normal cells, leading to significant systemic toxic side effects. As a result, there is pressing need for targeted drug delivery methods that can specifically target or tissues. Currently, researchers made progress in developing systems therapy using various targeting ligands. This review aims summarize recent advancements therapy, focusing on different ligands such as folic acid, carbohydrates, peptides, aptamers,...
Immunotherapy has emerged as a potential approach for breast cancer treatment. However, the rigid stromal microenvironment and low immunogenicity of tumors strongly reduce sensitivity to immunotherapy. To sensitize patients immunotherapy, hyaluronic acid-modified zinc peroxide–iron nanocomposites (Fe-ZnO2@HA, abbreviated FZOH) were synthesized remodel increase tumor immunogenicity. The constructed FZOH spontaneously generated highly oxidative hydroxyl radicals (·OH) that degrade acid (HA) in...
Exosomes are extracellular vesicles comprising bilayer phospholipid membranes and secreted by eukaryotic cells. They released via cellular exocytosis, contain DNA, RNA, proteins, other substances, participate in various communications between tissues organs. Since the discovery of exosomes 1983, animal-derived have become a research focus for small-molecule drug delivery biology, medicine, fields owing to their good biocompatibility homing effects. Recent studies found that plant-derived...
Astragalus polysaccharide (APS) derived from A. membranaceus plays a crucial role in traditional Chinese medicine. These polysaccharides have shown antitumor effects and are considered safe. Thus, they become increasingly important cancer immunotherapy. APS can limit the spread of by influencing immune cells, promoting cell death, triggering autophagy, impacting tumor microenvironment. When used combination with other therapies, enhance treatment outcomes reduce toxicity side effects....
Vitamin C (VC), also known as ascorbic acid, plays a crucial role water-soluble nutrient within the human body, contributing to variety of metabolic processes. Research findings suggest that increased doses VC demonstrate potential anti-tumor capabilities. This review delves into mechanisms absorption and its implications for cancer management. Building upon these foundational insights, we explore modern delivery systems VC, evaluating use in diverse treatment methods. These include...
Oncolytic Newcastle disease virus is a new type of cancer immunotherapy drug. This paper proposes scheme for delivering oncolytic viruses using hydrogel microneedles. Gelatin methacryloyl (GelMA) was synthesized by chemical grafting, and GelMA microneedles encapsulating (NDV) were prepared micro-molding photocrosslinking. The release expression NDV tested immunofluorescence hemagglutination experiments. experiments proved that successfully had characteristics. evenly dispersed in the...
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Due to the demand for efficient fine-tuning of large language models, Low-Rank Adaptation (LoRA) has been widely adopted as one most effective parameter-efficient methods. Nevertheless, while LoRA improves efficiency, there remains room improvement in accuracy. Herein, we adopt a novel perspective assess characteristics ranks. The results reveal that different ranks within modules not only exhibit varying levels importance but also evolve dynamically throughout process, which may limit...
Microneedles that can be inserted and attached to multiple organ sites are considered an innovative platform for delivering anti-tumor drugs, which used in various tumor treatment protocols.
Abstract Non-human primates (NHPs) represent the most valuable animals for drug discovery. However, current main challenge remains that NHP has not yet been used to develop an efficient translational medicine platform simulating human diseases, such as cancer. This study generated in situ gene-editing approach induce loss-of-function mutations of Pten and p53 genes rapid modeling primary metastatic liver tumors using CRISPR/Cas9 adult cynomolgus monkey. Under ultrasound guidance, was...
Malignant tumors are a major threat to human life and high lymphatic vessel density is often associated with metastatic tumors. With the discovery of molecules targeted at system such as endothelial hyaluronan receptor 1 (LYVE-1) Podoplanin, many studies have been performed determine role cells (LECs) in tumor metastasis. However, disadvantages non-specificity cost limit their research diagnostic applications. In this study, Fe3O4@KCTS, core-shell type magnetic nanoparticles, was prepared by...