A5102721115- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Ocular Surface and Contact Lens
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Electron Spin Resonance Studies
- Hemoglobin structure and function
- Atherosclerosis and Cardiovascular Diseases
- Allergic Rhinitis and Sensitization
- Glaucoma and retinal disorders
- Dermatology and Skin Diseases
Kyung Hee University
2023
Yonsei University
2012
Chung-Ang University Hospital
2000
Cornell University
1991
Laboratoire de Chimie
1990
Authentic N omega-hydroxy-L-arginine was synthesized and used to determine whether it is an intermediate in nitric oxide (.NO) synthesis from L-arginine by macrophage .NO synthase. The apparent Km (6.6 microM) Vmax (99 nmol x min-1 mg-1) observed with were similar those (Km = 2.3 microM; 54 mumol mg-1). omega-Hydroxy-D-arginine not a substrate. Stable isotope studies showed that synthase exclusively oxidized the hydroxylated nitrogen of omega-hydroxy-L-arginine, forming L-citrulline. As...
Previously proposed mechanisms for the production of L-citrulline from L-arginine by macrophage nitric oxide (NO.) synthase involve either hydrolysis arginine or hydration an intermediate and thus predict incorporation water oxygen into L-citrulline. Macrophage NO. was incubated with L-arginine, NADPH, tetrahydrobiopterin, FAD, dithiothreitol in H2(18)/16O2. L-Citrulline produced this reaction analyzed gas chromatography/mass spectrometry. Its mass spectrum matched that generated...
It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae periostracum (CP), slough Cryptotympana pustulata, has been frequently used for treating AD and skin affliction in traditional Korean Medicine. This study aimed at investigating ameliorating effects CP on its potential mechanism. The dinitrochlorobenzene (DNCB) sensitized mice were treated with 2 weeks. various biomarkers scores presented can...
Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts