A5092703373- Lipid Membrane Structure and Behavior
- Force Microscopy Techniques and Applications
- Caveolin-1 and cellular processes
- Steroid Chemistry and Biochemistry
- Nanopore and Nanochannel Transport Studies
- Cellular transport and secretion
- Cholesterol and Lipid Metabolism
University of Geneva
2023-2024
Biological membranes are partitioned into functional zones termed membrane microdomains, which contain specific lipids and proteins
Abstract Biological membranes are partitioned into functional zones containing specific lipids and proteins, termed membrane microdomains. Their composition organization remain controversial owing to a paucity of techniques that can visualize in situ without disrupting their native behavior 1,2 . The yeast eisosome, compartment scaffolded by the BAR-domain proteins Pil1 Lsp1, senses responds mechanical stress flattening releasing sequestered factors 3–7 Here, we isolated eisosomes as helical...
To maintain plasma membrane (PM) integrity, cells need to acutely regulate PM lipid composition. The Target Of Rapamycin (TOR) complex 2 is a protein kinase that acts as central regulator of homeostasis, but the mechanisms by which it monitors and reacts stresses are poorly understood. address this knowledge gap, we characterized family amphiphilic molecules physically perturb organization in doing so inhibit TORC2 yeast mammalian cells. Using fluorescent associated reporters budding yeast,...