A5039532332- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Risks and Factors
- interferon and immune responses
- Medical Imaging Techniques and Applications
- Urinary and Genital Oncology Studies
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Biology Techniques and Applications
- Economic and Financial Impacts of Cancer
- Peptidase Inhibition and Analysis
- Single-cell and spatial transcriptomics
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Multiple and Secondary Primary Cancers
Universität Hamburg
2023-2025
University Medical Center Hamburg-Eppendorf
2023-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Quantity and the spatial relationship of specific immune cell types can provide prognostic information in bladder cancer. The objective study was to characterize interplay role different subpopulations
563 Background: HCC MDTs involve specialists collaborating on patient cases to create personalized treatment plans. Implementing can be challenging in countries with limited resources and high disease burdens. In China, there were 368,000 new liver cancer 2022 representative of 40% global cases. Therefore, evaluating MDT practices at leading hospitals China may offer valuable insights that could help improve worldwide. Methods: This study selected distinct models: one for all patients...
Abstract Microsatellite instability is a strong predictor of response to immune checkpoint therapy and patient outcome in colorectal cancer. Although enrichment distinct T‐cell subpopulations has been determined impact the outcome, little known about underlying changes composition tumor microenvironment. To assess density, composition, degree functional marker expression, spatial interplay subpopulations, 79 microsatellite instable (MSI) 1,045 stable (MSS) cancers were analyzed. A tissue...
Abstract Quantification of tumor infiltrating lymphocytes (TILs) and immune checkpoints in the cancer microenvironment has become increasing interested immuno-oncology. Vulvar is emerging as a promising target for checkpoint blockade therapy. However, only little known about presence TILs expression molecules its predictive value vulvar cancer. To better comprehend role cell composition cancer, tissue microarray containing 479 samples with clinic-pathological data was analyzed by multiplex...
Abstract Lipid metabolism plays a pivotal role in shaping the tumor microenvironment, particularly by influencing macrophage function. This study aimed to identify lipid‐associated (LAM) marker genes involved onset and progression of non‐small cell lung cancer (NSCLC) through integrated single‐cell RNA sequencing (scRNA‐seq) bulk (bulk RNA‐seq) analyses. Mutation RNA‐seq data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases were analyzed explore relationship...
Prognostic markers in routine clinical management of breast cancer are often assessed using RNA-based multi-gene panels that depend on fluctuating tumor purity. Multiplex fluorescence immunohistochemistry (mfIHC) holds the potential for an improved risk assessment. To enable automated prognosis marker detection (i.e., progesterone receptor [PR], estrogen [ER], androgen [AR], GATA3, TROP2, HER2, PD-L1, Ki67, TOP2A), a framework identification was developed and validated involving thirteen...
Trophoblast cell surface antigen 2 (TROP2; EpCAM2) is a transmembrane glycoprotein which closely related to EpCAM (EpCAM; EpCAM1). Both proteins share partial overlapping functions in epithelial development and expression but have not been comparatively analyzed together bladder carcinomas. TROP2 constitutes the target for antibody-drug conjugate Sacituzumab govitecan (SG; TrodelvyTM) has approved treatment of metastatic urothelial carcinoma by United States Food Drug administration (FDA)...
Abstract Background: Microsatellite instability (MSI-h) is a strong biomarker to predict response immune checkpoint therapy and patient’s outcome in colorectal cancer. Although enrichment of distinct T-cell subpopulations, such as type 1 cytotoxic T-cells (Tc1) or helper (Th1), have been identified impact therapy, only little known about the underlying changes composition tumor microenvironment. Material Methods: To assess density, composition, degree functional marker expression, spatial...
Abstract Background: Although there is raising evidence that the density and level of immune checkpoint expression cell subpopulations are in direct contact to tumor cells (intraepithelial) can predict response therapy patient’s outcome, a comprehensive assessment intraepithelial their spatial interplay lacking. Material methods: To comprehensively assess density, expression, 48 expressing leukocyte 46 carcinoma entities, 4740 samples tissue microarray format were stained with 21 antibodies...
Abstract Background: Ki67 is expressed in the G1, S, G2 and M phase of cell cycle. Immunohistochemical determination labeling index (LI) a clinically well-established tool for assessing proliferative activity tumors critical clinical decisions are based on this parameter. Other cycle associated proteins have been evaluated utility much less intensively. This example includes minichromosome maintenance-3 (MCM3) which earlier than Ki67. Design: To evaluate difference potential synergy between...
Abstract Background: The stimulator of interferon genes (STING) is a transmembrane protein expressed on variety cell types including epithelial, inflammatory (lymphocytes and macrophages), endothelial cells. STING expression has been described at variable levels in various tumor where it might enhance anti-tumoral effects the immune system impact angiogenesis. activating targeted therapies are currently evaluated preclinical studies. However, clinical significance cells as compared to...
Abstract Background: A combination of different immune-checkpoint-inhibitors (ICIs) have shown remarkable success in several tumor entities. However, the likelihood positive response to ICIs is poor most entities and recent evidence suggests that quantity expression level immune checkpoints such as TIM3, CTLA-4, PD-1 infiltrating lymphocytes (TILs) influences checkpoint inhibitors. Design: To assess density spatial interplay 42 expressing leukocyte subpopulations 6031 samples from 49...
Abstract Background: The composition and functional state of T-cell subpopulations can highly impact patient’s outcome response to immune checkpoint therapy. However, only little is known about the spatial interplay most rare subpopulations. Design: To assess density, composition, degree expression, in 5989 tumor samples from more than 100 entities, two different types tissue microarrays (0.6 mm 4 diameter) were stained with antibodies directed against CD3, CD4, CD8, FOXP3, T-bet, GATA3,...