A5093279114- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Phosphodiesterase function and regulation
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Diabetes Treatment and Management
- Adenosine and Purinergic Signaling
- Obesity, Physical Activity, Diet
Noakhali Science and Technology University
2023-2024
Obesity is a chronic condition which identified by the buildup of excess body fat caused combination various factors, including genetic predisposition and lifestyle choices. rs1137101 (A > G) polymorphism in CHR1 domain LEPR protein linked to different diseases obesity. Nevertheless, connection between this likelihood developing obesity has not been determined definitively. Therefore, meta-analysis was conducted assess relationship risk The included all studies meeting pre-defined criteria,...
Tumor suppressor cylindromatosis protein (CYLD) regulates NF-κB and JNK signaling pathways by cleaving K63-linked poly-ubiquitin chain from its substrate molecules thus preventing the progression of tumorigenesis metastasis cancer cells. Mutations in CYLD can cause aberrant structure abnormal functionality leading to tumor formation. In this study, we utilized several computational tools such as PANTHER, PROVEAN, PredictSNP, PolyPhen-2, PhD-SNP, PON-P2, SIFT find out deleterious nsSNPs. We...
Type 2 Diabetes Mellitus (T2DM) occurs due to a complex relationship of genetic, environmental, and physiological factors, encompassing insufficient pancreatic insulin synthesis, peripheral resistance, diverse molecular pathways. The transmembrane glycoprotein ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) plays role in regulation, with the K121Q (rs1044498) variant on ENPP1 gene being subject extensive study its potential association T2DM. To comprehensively evaluate this...
Abstract Tumor suppressor Cylindromatosis protein (CYLD) regulates NF- κB and JNK signaling pathway by cleaving K63 linked poly-ubiquitin chain from its substrate molecules thus preventing the progression of tumorigenesis metastasis cancer cells. Mutations in CYLD can cause aberrant structure abnormal functionality leading to tumor formation. In this study, we utilized several computational tools such as PANTHER, PROVEAN, PREDICT- SNP, POLYPHEN 2, PHD PON P2, SIFT find out deleterious...