A5100767948- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Anesthesia and Pain Management
- MicroRNA in disease regulation
- Nausea and vomiting management
- Lipoproteins and Cardiovascular Health
- Metabolomics and Mass Spectrometry Studies
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Anesthesia and Sedative Agents
- Osteoarthritis Treatment and Mechanisms
- Neuroscience of respiration and sleep
- Peroxisome Proliferator-Activated Receptors
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Advanced Biosensing Techniques and Applications
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Disease Prevention
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Glycosylation and Glycoproteins Research
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Spinal Cord Injury Research
Southern Medical University
2021-2025
Second Affiliated Hospital of Fujian Medical University
2014-2025
Fujian Medical University
2013-2025
Guangdong Provincial People's Hospital
2020-2025
Guangdong Academy of Medical Sciences
2018-2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Wuhan University
2022-2025
Hebei Medical University
2017-2024
Second Hospital of Hebei Medical University
2017-2024
Sevoflurane post-conditioning exerts nerve-protective effects through inhibiting caspase-dependent neuronal apoptosis after a traumatic brain injury (TBI). Autophagy that is induced by the endoplasmic reticulum stress plays an important role in secondary neurological dysfunction TBI. However, relationship between autophagy and as well underlying nerve protection mechanism occurs with sevoflurane following TBI remains unclear.The Feeney model was used to induce rats. Evaluation of modified...
Abstract Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared diffuse large B‐cell lymphoma or acute lymphoblastic leukemia. Impaired T‐cell fitness CLL patients may involved failure. Less‐differentiated naïve‐like play an important role CART expansion and long‐term persistence vivo. These are sparse patients. Therefore, optimization cell production...
Selective, efficient, and controllable oxidation of cytosine modifications is valuable for epigenetic analyses, yet only limited progress has been made. Here, we present two modular chemical reactions: conversion 5-hydroxymethylcytosine (5hmC) into 5-formylcytosine (5fC) using 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (ACT+BF4–) further transformation 5fC 5-carboxycytosine (5caC) through Pinnick oxidation. Both reactions are mild efficient on double-stranded...
The present study aimed to investigate whether dihydroartemisinin (DHA) alleviates osteoarthritis (OA) in a mouse model of OA. Ten‑week‑old female C57BL/6j mice were used establish OA models by anterior cruciate ligament transection (ACLT) and ovariectomized (OVX). DHA was then treat the ACLT OVX mice. Safranin O‑fast green staining Osteoarthritis Research Society International (OARSI)‑modified Mankin scores grade articular cartilage degeneration. Expression metalloproteinase‑13 (MMP‑13)...
Abstract Long-read sequencing provides valuable information on difficult-to-map genomic regions, which can complement short-read to improve genome assembly, yet limited methods are available accurately detect DNA methylation over long distances at a whole-genome scale. By combining our recently developed TET-assisted pyridine borane (TAPS) method, enables direct detection of 5-methylcytosine and 5-hydroxymethylcytosine, with PacBio single-molecule real-time sequencing, we present here...
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes CAD and their potential causal effects impacts left ventricular remodeling remains limited. We aim to assess contribution plasma metabolites risk death major adverse cardiovascular events (MACE) as well remodeling. Results In prospective study with 1606 Chinese patients CAD, we have identified validated several independent through...
To investigate the independent risk factors associated with postoperative nausea and vomiting (PONV) following Cesarean section procedures, establish validate a nomogram to predict them. The clinical data of 116 adult patients who underwent procedures between August 2022 February 2023 were included. Participants randomly divided into training (n = 87) verification sets 29) in 3:1 ratio. Univariate multivariate logistic regression used analyze for PONV sections then prediction model....
Background: Strategies for predicting the recurrence of nasopharyngeal carcinoma need to be further development and validation. We developed a prediction model based on fusion multi-omics features from pre-treatment conventional magnetic resonance sequences (CE-T1W) in (NPC) patients predict posttreatment recurrence. Methods: employed deep unsupervised stacked denoising autoencoder (stacked autoencoder, SDAE) feature method develop an NPC model. Data images 184 with newly diagnosed (NPC),...
Purpose: The epigenetic deregulation of CpG islands (CGIs) plays a crucial role in cancer initiation and progression. Genome-wide analysis aberrant methylation patterns CGIs offers promising approach for the early detection. However, clinical utility whole genome bisulfite sequencing is limited by need high coverage to achieve sensitive To address this challenge, we have developed aMAPP, method that enriches hypermethylated and/or hypomethylated CGIs. This enables detection tracing patterns,...
Lipoprotein (a) [Lp(a)] is a genetically determined risk factor of coronary artery disease (CAD). Previous genome-wide association studies (GWASs), which were mostly carried out in Caucasians, have identified many Lp(a)-associated SNPs. Here, we performed GWAS on Lp(a) levels and further explored the relationships between SNPs CAD severity 1,403 Han Chinese subjects. We observed that elevated significantly associated with increased synergy percutaneous intervention TAXUS cardiac surgery...
Purpose: To investigate whether systemic injection of rapamycin attenuates articular cartilage degeneration by inhibiting β-catenin in a murine model osteoarthritis (OA). Materials and methods: Ten-week-old male C57BL/6j wild-type (WT) mice SOST-knockout (SOST-/-) were randomized to sham group, vehicle-treated rapamycin-treated group. Mice the group underwent destabilizing medial meniscus (DMM) right knee, then treated with vehicle. treatment DMM rapamycin. Safranin O-Fast green staining...
Background and Aim: Osteoarthritis is a disease that accompanied by inflammation catabolic disorders in the cartilage. Rapamycin good autophagy activator has an inhibitory effect on inflammation, can remove waste generated delay destruction of cartilage inflammation. This study was designed to evaluate rapamycin upon catabolism human chondrocytes unravel underlying mechanism. Methods Results: C57 mice SW1353 cells were cultured osteoblastic arthritis formed destabilization medial meniscus...