A5048743928- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Diabetes Management and Research
- Pancreatic function and diabetes
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Cellular Mechanics and Interactions
- Soft Robotics and Applications
- Diabetes and associated disorders
Ollscoil na Gaillimhe – University of Galway
2021-2023
Explora (Italy)
2021
The foreign body response impedes the function and longevity of implantable drug delivery devices. As a dense fibrotic capsule forms, integration device with host tissue becomes compromised, ultimately resulting in seclusion treatment failure. We present FibroSensing Dynamic Soft Reservoir (FSDSR), an capable monitoring formation overcoming its effects via soft robotic actuations. Occlusion FSDSR porous membrane was monitored over 7 days rodent model using electrochemical impedance...
The foreign body response (FBR) to implanted materials culminates in the deposition of a hypo-permeable, collagen rich fibrotic capsule by myofibroblast cells at implant site. can be deleterious function some medical implants as it isolate from host environment. Modulation formation has been achieved using intermittent actuation drug delivery implants, however mechanisms underlying this are not well understood. Here, we use analytical, computational, and vitro models understand human...
Duffy Lab Group, National University of Ireland Galway. Introduction: Over 60% islets transplanted in macrodevices are lost immediately post transplantation due to hypoxia from inadequate early vascularisation [1][2][3]. Prevascularisation the implant site by spatiotemporally delivering vascular endothelial growth factor (VEGF), most prominent angiogenic [4], is a potential solution [5]. VEGF has half-life only 50 mins at body temperature [6][7] meaning multiple, large doses required if...