A5088809065- Photoacoustic and Ultrasonic Imaging
- Cytokine Signaling Pathways and Interactions
- Synthesis and biological activity
- Ultrasound and Hyperthermia Applications
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Ultrasound Imaging and Elastography
- Genomics and Chromatin Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Ultrasound and Cavitation Phenomena
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Fungal Plant Pathogen Control
- Peptidase Inhibition and Analysis
ShanghaiTech University
2024
Beijing Radiation Center
2024
Wenzhou Medical University
2024
Universidad de Málaga
2016
Introduction: Cancer, a significant global health concern, necessitates innovative treatments. The pivotal role of chronic inflammation in cancer development underscores the urgency for novel therapeutic strategies. Benzothiazole derivatives exhibit promise due to their distinctive structures and broad spectrum biological effects. This study aims explore new anti-tumor small molecule drugs that simultaneously anti-inflammatory anticancer based on advantages benzothiazole frameworks. Methods:...
Recently, our group developed a synergistic brain drug delivery method to achieve simultaneous transcranial hyperthermia and localized blood–brain barrier opening via MR-guided focused ultrasound (MRgFUS). In rodent model, we demonstrated that the power required for MRgFUS was significantly reduced by injecting microbubbles (MBs). However, specific mechanisms underlying reduction caused MBs remain unclear. The present study aims elucidate of MB-enhanced through numerical studies using finite...
<title>Abstract</title> Alterations in 3D chromatin conformation may disrupt the interplay between promoters and distal enhancers. How gene regulatory circuits are reshaped during ionizing radiation-induced tumorigenesis remains unclear, little is known about mediators that drivethese processes. To decipher alterations lung cancer, we performed ATAC-seq, RNA-seq Hi-C analyses of human bronchial epithelial cells corresponding malignant transformed cell lines. We found this transformation...
Abstract Transcranial focused ultrasound (tFUS) is an emerging modality with strong potential for non‐invasively treating brain disorders. However, the inhomogeneity and complex structure of skull induce substantial phase aberrations pressure attenuation; these can distort shift acoustic focus, thus hindering efficiency tFUS therapy. To achieve effective treatments, phased array transducers combined aberration correction algorithms are commonly implemented. The present report aims to provide...