A5015583615- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Epigenetics and DNA Methylation
- Asymmetric Synthesis and Catalysis
- Mass Spectrometry Techniques and Applications
- Chromatography in Natural Products
- Hydrocarbon exploration and reservoir analysis
- Click Chemistry and Applications
- Liver physiology and pathology
- Rock Mechanics and Modeling
- Crystallization and Solubility Studies
- Metabolomics and Mass Spectrometry Studies
- Cyclopropane Reaction Mechanisms
- RNA modifications and cancer
- Atmospheric and Environmental Gas Dynamics
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Carbohydrate Chemistry and Synthesis
- Coal Properties and Utilization
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Hydraulic Fracturing and Reservoir Analysis
- Molecular Biology Techniques and Applications
Hubei University of Medicine
2024
Taihe Hospital
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024
Novartis (United States)
2023
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Amgen (United States)
2020
Ministry of Natural Resources
2017-2019
China University of Geosciences (Beijing)
2017-2019
Sichuan University
2007
Background: Overexpression of solute carrier family 7 member 8 (SLC7A8) has been shown to relate the survival time and tumor progression in cancer patients. However, role SLC7A8 lung adenocarcinoma (LUAD) is still obscure. Method: The relationships between expression LUAD tissues clinical values as well immune infiltration were explored through bioinformatics. functions pathways investigated using Kyoto Encyclopedia Genes Genomes enrichment analysis, Gene Set Enrichment Analysis, Western...
Abstract The supercritical fluid chromatographic separation of underivatized amino acids was explored using immobilized chiral crown ether column CROWNPAK CR‐I (+) and mass spectrometric detection. type modifier, acidic additives, the role water were investigated. Enantioseparation achieved for all 18 investigated with short retention times (less than 3 minutes) average resolution greater 5.0. Analysis enantiomerically pure standards demonstrated D enantiomer eluted first a column.
Knowledge of the gas adsorption rate and diffusion characteristics in shale are very important to evaluate transport properties. However, research on methane behavior is not well established. In this study, high-pressure isotherms data from four marine samples were obtained by recording pressure changes against time at 1-s intervals for 12 steps. Seven steps selected modelling, three low (~0.4 MPa), medium (~4.0 high (~7.0 MPa) display. According results under attained equilibrium much more...
Recent years have seen novel modalities emerge for the treatment of human diseases resulting in an increase beyond rule 5 (bRo5) chemical matter. As a result, synthetic innovations aiming at enabling rapid access complex bRo5 molecular entities become increasingly valuable medicinal chemists’ tool-kits. Herein, we report general synthesis new class noncanonical amino acids (ncAA) with cyclopropyl back-bone to achieve conformational constraint and bearing C(sp3)-rich benzene bioisosteres. We...
Recent years have seen novel modalities emerge for the treatment of human diseases resulting in an increase beyond rule 5 (bRo5) chemical matter. As a result, synthetic innovations aiming to enable rapid access complex bRo5 molecular entities become increasingly valuable medicinal chemists' toolkits. Herein, we report general synthesis new class noncanonical amino acids (ncAA) with cyclopropyl backbone achieve conformational constraint and bearing C(sp3)-rich benzene bioisosteres. We also...
Abstract In this study, crown ether‐derived column Crownpak® CR‐I (+) was evaluated under SFC conditions using 12 primary amines, and the chromatographic results were compared against eight immobilized polysaccharide‐based columns. achieved a significantly higher success rate. It found that addition of 5% water to modifier dramatically improved peak shape for chiral separation amines on (+). The first reported preparative separations are shown, offering new approach resolution amines. case...
Abstract In this study, the performance of widely used “golden four” coated chiral stationary phases (Chiralpak AD‐3, Chiralcel OD‐3, Chiralpak AS‐3, and OJ‐3) was compared with their corresponding immobilized versions IA‐3, IB‐3, IB N‐3, IH‐3, IJ‐3) under supercritical fluid chromatography (SFC) conditions a set 30 racemic compounds. Using traditional modifiers, methanol isopropanol, columns N‐3 IH‐3) showed an improved general ability to successfully resolve enantiomers target analytes...
Schema 2 dieser Zuschrift zeigt eine fehlerhafte Struktur für den Katalysator 1 c. Die korrekte dieses chiralen primären Amins ist hier abgebildet.1
In Scheme 2 of this Communication, structure 1 c was shown incorrectly. The correct chiral primary amine catalyst is below.1