A5006857382- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- RNA modifications and cancer
University of Science and Technology of China
2021-2025
Shenzhen Bay Laboratory
2025
Estrogen signaling dysregulation plays a critical role in the development of anti-estrogen resistance and bone metastasis ER+ mammary carcinoma. Using quantitative proteomic screening, we identified FXR1 as an estrogen-regulated RNA-binding protein associated with resistance. Mechanistically, estrogen IGF1 facilitate translation via PI3K/AKT/mTOR/EIF4E pathway. enhances cellular to apoptosis ferroptosis by facilitating maturation BCL2 pre-mRNA stabilizing GPX4 mRNA, respectively....
Abstract Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as exhibiting strong association with ERα signaling high specificity expression tissue. ERLC1 transcriptionally activated by ERα, stabilized ESR1 transcript sequestering miR-129 tethering FXR1 to maintain positive feedback loop that potentiated signaling. elevated...
<div>Abstract<p>Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as exhibiting strong association with ERα signaling high specificity expression tissue. ERLC1 transcriptionally activated by ERα, stabilized <i>ESR1</i> transcript sequestering miR-129 tethering FXR1 to maintain positive feedback loop...
<p>Supplementary table S1 lists 22 breast cancer and ERα associated lncRNAs. Supplementary S2 all primers sequences, oligonucleotides probes sequences used in this study. S3 shows the information of antibodies S4 sequence ERLC1 overexpression system. figure that is screened as an ERα-regulated gene cancer. oncogene MCF-7 T47D cells. regulates anti-estrogen sensitivity tamoxifen resistance miR-129 a tumor suppressor expression negatively correlated with levels. S5 promotes ESR1 through...
<div>Abstract<p>Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as exhibiting strong association with ERα signaling high specificity expression tissue. ERLC1 transcriptionally activated by ERα, stabilized <i>ESR1</i> transcript sequestering miR-129 tethering FXR1 to maintain positive feedback loop...
<p>Supplementary table S1 lists 22 breast cancer and ERα associated lncRNAs. Supplementary S2 all primers sequences, oligonucleotides probes sequences used in this study. S3 shows the information of antibodies S4 sequence ERLC1 overexpression system. figure that is screened as an ERα-regulated gene cancer. oncogene MCF-7 T47D cells. regulates anti-estrogen sensitivity tamoxifen resistance miR-129 a tumor suppressor expression negatively correlated with levels. S5 promotes ESR1 through...