A5112656283- Hematopoietic Stem Cell Transplantation
- HIV/AIDS Research and Interventions
- Mesenchymal stem cell research
- HIV, Drug Use, Sexual Risk
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Dementia and Cognitive Impairment Research
- Influenza Virus Research Studies
- CAR-T cell therapy research
- Intergenerational Family Dynamics and Caregiving
- Pluripotent Stem Cells Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Cancer-related cognitive impairment studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Healthcare Operations and Scheduling Optimization
- Psychological Treatments and Assessments
- HIV-related health complications and treatments
- Mycotoxins in Agriculture and Food
St Vincent's Hospital Sydney
2008-2025
UNSW Sydney
2020-2025
Royal North Shore Hospital
2025
The University of Sydney
2025
New York University
2021-2025
St Vincent's Health
2025
Servicio Diabetología Hospital Córdoba
2006-2022
St Vincent's Clinic
2020-2022
National University of Comahue
2021
St Vincent's Hospital
2010-2020
The standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL) is salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT). impact of maintenance rituximab after ASCT not known.In total, 477 patients with CD20(+) DLBCL who were in their first relapse or refractory to initial randomly assigned one two regimens. After three cycles chemotherapy, the responding received ASCT. Then, 242 either every 2 months 1 year observation.After ASCT, 122...
Intervertebral disc degeneration is a major cause and risk factor for chronic low back pain. The potential of using stem cells to treat has been raised. aims our study were assess whether xenogeneic bone-marrow derived could survive in rat model determine which cell types, if any, survived differentiated into disc-like cells. Human CD34(+) (hematopoietic progenitor cells) CD34(-) (nonhematopoietic cells, including mesenchymal isolated, fluorescent-labeled, injected coccygeal discs. rats...
Background Data from prospectively planned cohort studies on risk of major clinical outcomes and prognostic factors for patients with influenza A(H1N1)pdm09 virus are limited. In 2009, in order to assess evaluate progression illness, two were initiated: FLU 002 outpatients 003 hospitalized patients. Methods Findings Between October 2009 December 2012, adults influenza-like illness (ILI) enrolled; followed 14 days inpatients 60 days. Disease was defined as hospitalization and/or death...
Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor p53, has been gaining increasing interest as a strategy for treatment acute myeloid leukemia (AML). While clinical trials MDM2 inhibitors have shown promise, responses confined to largely molecularly undefined patients, indicating that new biomarkers and optimized strategies are needed. We previously reported microRNA miR-10a is strongly overexpressed in some AML, demonstrate here it modulates several key...
Clonal haematopoiesis of indeterminate potential (CHIP) is an aging-associated phenomenon that has recently been correlated with a broad spectrum human diseases, including haematological malignancy, cytopenia, coronary heart disease, stroke, and overall mortality. CHIP defined as somatic variant in blood cells allele frequency (VAF) ≥ 0.02, however recent reports show smaller clones are associated poorer clinical outcome. Error-corrected ultradeep next-generation sequencing (NGS) assays...
Abstract Background Assessment of patient readiness for hospital discharge has been advocated as an important component preparation. However, no measures focused on hospital-to-home transitions patients receiving a palliative approach to care, or the associated difficulties in coping at home after discharge, have developed date. Using co-design approach, purpose this study was (1) adapt two scales care population, one which assess transition and another difficulty post-transition (2) test...
Induced pluripotent stem cells (iPSCs) are an invaluable resource for the study of human disease. However, there no standardized methods differentiation into hematopoietic cells, and is a lack robust, direct comparisons different methodologies. In current we improved feeder-free, serum-free method generation from iPSCs, directly compared this with three other commonly used strategies respect to efficiency, repeatability, hands-on time, cost. We also investigated their capability sensitivity...
Because of advances in hematopoietic cell transplant (HCT), meeting the long-term health needs increasing numbers HCT survivors remains challenging. This multicenter trial aimed to assess short- and effects an exercise mindfulness intervention delivered by telehealth. One hundred thirty-nine participants >6 months post-HCT were randomly assigned 1:1 a 6-week personalized training with three motivation sessions at 3-6 via online platform or usual care. Physical quality-of-life (QOL)...
Abstract Background Outcome data from prospective follow-up studies comparing infections with different influenza virus types/subtypes are limited. Methods Demographic, clinical characteristics and outcomes for adults laboratory-confirmed A(H1N1)pdm09, A(H3N2), or B were compared in 2 cohorts enrolled globally 2009 through 2015. Logistic regression was used to compare among type/subtypes. Results Of 3952 outpatients, 1290 (32.6%) had A(H1N1)pdm09 infection, 1857 (47.0%) 805 (20.4%) B. 1398...
Behçet's Disease (BD) is an autoimmune disease mostly presenting with recurrent oral and genital aphthosis, uveitis. Patients are rarely refractory to immunosuppressive treatments. Autologous hematopoietic stem cell transplantation (aHSCT) a standard of care in other diseases. Some patients BD have been treated aHSCT based on compassionate use.Evaluate the outcome adult member centers European Society for Blood Marrow Transplantation (EBMT).Adults who received primarily were identified...
Behavioral interventions can reduce distress for couples coping with early-stage dementia. However, most are limited in accessibility and fail to address individualized goals. This pilot study examined the dyadic effects on multiple indicators of well-being Wish Outcome Obstacle Plan (WOOP) intervention, which guides participants use Mental Contrasting Implementation Intentions achieve attainable goals their daily lives. randomized controlled trial included 45 older persons dementia (PWD)...
Anaplastic thyroid carcinoma is a highly malignant tumor in elderly people with long history of multinodular goiter and usually associated rapidly fatal clinical evolution. The often develops as result anaplastic transformation slowly growing papillary or follicular neoplasm.An 85-year-old woman had been asymptomatic, normal white blood cell count chest radiograph three months prior to her hospital admission for the treatment. presented low grade fever, leukocytosis, multiple metastatic lung...
The Delta/Notch signal transduction pathway is central to T cell differentiation from haemopoietic stem cells (HSCs). Although development well characterized using expression of surface markers, the detailed mechanisms driving have not been established. This issue becomes with observations that adult HSCs exhibit poor towards lineage relative neonatal or embryonic precursors. study investigates contribution Notch signalling and stromal support Cord Blood (CB) human HSCs, OP9Delta co-culture...