A5103192406- Atherosclerosis and Cardiovascular Diseases
- Celiac Disease Research and Management
- Cholesterol and Lipid Metabolism
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Enzyme Structure and Function
- Evolution and Genetic Dynamics
- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Cell Adhesion Molecules Research
- Barrier Structure and Function Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Congenital gastrointestinal and neural anomalies
- Sphingolipid Metabolism and Signaling
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
University of Lausanne
2019-2025
University Hospital of Lausanne
2021
Villanova University
2018
Temple University
2017
Ursinus College
2017
Abstract The vasculature is a key regulator of leukocyte trafficking into the central nervous system (CNS) during inflammatory diseases including multiple sclerosis (MS). However, impact endothelial‐derived factors on CNS immune responses remains unknown. Bioactive lipids, in particular oxysterols downstream Cholesterol‐25‐hydroxylase (Ch25h), promote neuroinflammation but their functions are not well‐understood. Using floxed‐reporter Ch25h knock‐in mice, we trace expression to endothelial...
Antibody-producing plasma cells fuel humoral immune responses. They also contribute to autoimmune diseases such as systemic lupus erythematosus or IgA nephropathy. Interleukin-6 and the tumor necrosis factor (TNF) family ligands BAFF (B cell-activating factor) APRIL (a proliferation-inducing ligand) participate in cell survival. binds three receptors, BAFFR (BAFF receptor), TACI (transmembrane activator CAML interactor), BCMA maturation antigen), while TACI, BCMA, proteoglycans. However,...
Celiac disease, a gluten-sensitive enteropathy, demonstrates strong human leukocyte antigen (HLA) association, with more than 90% of patients carrying the HLA-DQ2.5 allotype. No therapy is available for condition except lifelong gluten-free diet. To address this gap, we explored therapeutic potential regulatory T cells (Tregs). By orthotopic replacement cell receptors (TCRs) through homology-directed repair, generated gluten-reactive HLA-DQ2.5-restricted CD4+ engineered (e) effector (Teffs)...
Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS) commonly affecting young adults. There increasing evidence that environmental factors are important in development and course MS. The metabolic syndrome (MetS) which comprises dyslipidemia has been associated with worse outcome MS disease. Furthermore, lipid-lowering drug class statins proposed to improve course. However, cholesterol also rate-limiting for myelin biogenesis promotes remyelination...
Improvements in the description of amino acid substitution are required to develop better pseudo-energy-based protein structure-aware models for use phylogenetic studies. These used characterize probabilities and enable simulation sequences over a phylogeny. A characterization turn enables numerous downstream applications, like detecting positive selection, ancestral sequence reconstruction, evolutionarily-motivated engineering. Many existing Markov molecular evolution disregard structure...
The TNF family ligands, B cell activating factor of the (BAFF, also known as lymphocyte stimulator, BLyS) and a proliferation-inducing ligand (APRIL), share transmembrane activator calcium-modulator cyclophilin (CAML)-interactor (TACI) one their common receptors. Atacicept, chimeric recombinant TACI/IgG1-Fc fusion protein, inhibits both ligands. TACI APRIL bind to proteoglycans heparin that is structurally related proteoglycans. It unknown whether portion contained in atacicept can directly...
Helicobacter pylori is a human stomach pathogen, naturally-competent for DNA uptake, and prone to homologous recombination. Extensive homoplasy (i.e., phylogenetically-unlinked identical variations) observed in H. genes considered hallmark of such However, also exhibits high mutation rate. The relative adaptive role recombination species diversity highly-debated issue biology. Recombination results homoplasy. While convergent can account homoplasy, its contribution thought be minor. We...
Disruption of gut barrier function and intestinal immune cell homeostasis are increasingly considered critical players in pathogenesis extra-intestinal inflammatory diseases, including multiple sclerosis (MS) its prototypical animal model, the experimental autoimmune encephalomyelitis (EAE). Breakdown epithelial barriers increases permeability systemic dissemination microbiota-derived molecules. However, whether gut-vascular (GVB) is altered during EAE has not been reported. Here, we...
Sunday, April 26April 14, 2020Free AccessImpact of Oxysterols on the Gut-brain Axis During Experimental Autoimmune Encephalomyelitis (2076)Donovan Duc, Solenne Vigne, Benjamin Peter, Yannick Yersin, Florian Ruiz, and Caroline PotAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.2076 Letters to Editor
Abstract Background: Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS) commonly affecting young adults. There increasing evidence that environmental factors are important in development and course MS. Metabolic syndrome (MetS) including dyslipidemia has been associated with worse outcome MS disease. Furthermore, lipid lowering drugs statins have proposed to improve course. However, cholesterol also rate-limiting for myelin biogenesis promotes...