A5110040795- Respiratory viral infections research
- Infectious Disease Case Reports and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Cellular Mechanics and Interactions
- Influenza Virus Research Studies
- 3D Printing in Biomedical Research
- Genetics, Bioinformatics, and Biomedical Research
- Health Education and Validation
- Multiple Sclerosis Research Studies
- Microtubule and mitosis dynamics
- Delphi Technique in Research
- Blood properties and coagulation
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Erythrocyte Function and Pathophysiology
- Pediatric health and respiratory diseases
- Health Sciences Research and Education
Pulmotect (United States)
2017-2023
Yonsei University
2008
Assiut University
2008
Rice University
2002-2003
Dictyostelium aggregation streams break up into groups of 103 to 2×104 cells. The cells sense the number in a stream or group by level secreted counting factor (CF). CF is complex at least 5 polypeptides. When gene encoding countin (one polypeptides) was disrupted, could not each other’s presence, resulting non-breaking that coalesced abnormally large groups. To understand function components CF, we have isolated cDNA sequences second component CF50. CF50 30% identical lysozyme (but has very...
ABSTRACT Developing Dictyostelium cells aggregate to form fruiting bodies containing typically 2 × 10 4 cells. To prevent the formation of an excessively large body, streams aggregating break up into groups if there are too many The breakup is regulated by a secreted complex polypeptides called counting factor (CF). Countin and CF50 two components CF. Disrupting expression either these proteins results in secreting very little detectable CF activity, as result, aggregation remain intact...
Pneumonia caused by the intracellular bacterium Rhodococcus equi is an important cause of disease and death in immunocompromised hosts, especially foals. Antibiotics are standard care for treating R. pneumonia foals, adjunctive therapies needed. We tested whether nebulization with TLR agonists (PUL-042) foals would improve innate immunity reduce severity duration following infection. Neonatal (n = 48) were nebulized either PUL-042 or vehicle, their lung cells infected ex vivo. increased...
Airway mucus is a component of the lung's innate immune defense that forms protective barrier against inhaled particles and pathogens.Upon inflammatory stimulation, airway epithelium undergoes significant change in structure function, due to increased mucin production by Clara cells.However, excessive secretion or failure mucociliary clearance causes airflow obstruction promotes infections.The precise mechanisms these pathologic processes are not well understood at molecular, cellular,...
Abstract Pneumonia caused by Rhodococcus equi, an intracellular bacterium that infects macrophages, is important cause of disease and death in immunocompromised hosts, especially foals. No vaccine available, control based on antibiotic treatment subclinical cases, increasing the pressure for emergence resistance indicating novel approaches are needed. TLR agonists have immunomodulatory function. Our first objective was to evaluate ex vivo effects neonatal foal alveolar macrophages (AMs) with...
pancreatitis are very variable and comparisons should be made cautiously.Corlett Mishell considered early diag- nosis to important in the management of disease.Apart from pethidine debatable use anticholinergics they sug- gest giving dextran decrease pancreatic secretions.They also suggest saline intravenously initially since blood sugar levels influence secretions, both exocrine endocrine.However, there is probably an equally good argument for dextrose prevent any vagal stimulation...