A5102719008- Heme Oxygenase-1 and Carbon Monoxide
- Fibroblast Growth Factor Research
- Bone Metabolism and Diseases
- Polymer Surface Interaction Studies
- Blood Coagulation and Thrombosis Mechanisms
- Plant biochemistry and biosynthesis
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Biomarkers in Disease Mechanisms
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mesenchymal stem cell research
- Hydrogen's biological and therapeutic effects
- Pluripotent Stem Cells Research
- Zebrafish Biomedical Research Applications
- Hair Growth and Disorders
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Organ Transplantation Techniques and Outcomes
- Platelet Disorders and Treatments
- Plant Gene Expression Analysis
- Neonatal Health and Biochemistry
Nanjing University
2025
Nanjing General Hospital of Nanjing Military Command
2025
Qingdao Agricultural University
2023
Ministry of Agriculture and Rural Affairs
2023
Northwestern Polytechnical University
2022
Wenzhou Medical University
2020-2021
Southern Medical University
2015
Nanfang Hospital
2015
Ningbo University
2014
Southwest Jiaotong University
2013
Hyperoxia causes cell injury and death associated with reactive oxygen species formation inflammatory responses. Recent studies show that hyperoxia-induced involves apoptosis, necrosis, or mixed phenotypes depending on type, although the underlying mechanisms remain unclear. Using murine lung endothelial cells, we found hyperoxia caused by apoptosis involving both extrinsic (Fas-dependent) intrinsic (mitochondria-dependent) pathways. Hyperoxia-dependent activation of pathway death-inducing...
Abstract Brain endothelial cell (bEC) dysfunction is the main factor of blood-brain barrier (BBB) breakdown, which triggers a vicious cycle aggravating traumatic brain injury (TBI) pathogenesis. Previous studies have revealed that neutrophil extracellular traps (NETs) released by neutrophils can lead to BBB disruption, but there lack research on underlying mechanisms after TBI. Here, excessive NETs were found in both contused tissue and circulation following We could activate TLR4/NF-κB...
Ischemic strokes account for about 80% of all and are associated with a high risk mortality. Angiogenesis brain microvascular endothelial cells may contribute to functional restoration following ischemia. Fibroblast growth factor 1 (FGF1), member FGF superfamily, involved in embryonic development, angiogenesis, wound healing, neuron survival. However, the mitogenic activity FGF1 is known several human pathologies, thereby questioning safety its clinical applications. Here, we explored...
Osteoporosis is one of the most common bone disorders that seriously affect health and life quality elderly individuals. Reduced osteoblast differentiation formation lead to changes in volume microarchitecture, leaving bones vulnerable fracture. Bergamottin (BM) a natural compound derived from various citrus fruits possesses multiple biological activities including anti-adipogenesis function. This study aimed evaluate effects BM on its potential anti-osteoporosis capacity, as well explore...
Abstract Salinity is a severe abiotic stress that limits plant survival, growth, and development. 14-3-3 proteins are phosphopeptide-binding involved in numerous signaling pathways, such as metabolism, development, responses. However, their roles salt tolerance unclear woody plants. Here, we characterized an apple (Malus domestica) gene, GENERAL REGULATORY FACTOR 8 (MdGRF8), the product of which promotes salinity tolerance. MdGRF8 overexpression improved plants, whereas MdGRF8-RNA...
It has been reported that collagenases (matrix metalloproteinase 2 [MMP-2] and matrix 9 [MMP-9]) are associated with hair cycle, whereas the mechanism of association is largely unknown.The mice were randomly allocated into four groups: saline, 5, 10, 15 nM SB-3CT. Immunohistochemical analysis was employed to examine MMP-2 MMP-9 protein. Real-time polymerase chain reaction enzyme-linked immunosorbent assay performed determine mRNA protein levels VEGF, IGF-1, TGF-β, GAPDH. Growing follicles...
The pathology of cerebrovascular disorders takes an important role in traumatic brain injury (TBI) by increasing intracranial pressure. Fibroblast growth factor 20 (FGF20) is a brain-derived neurotrophic factor, that has been shown to play the survival dopaminergic neurons and treatment Parkinson's disease (PD). However, little known about FGF20 TBI its underlying mechanism. purpose this study was evaluate protective effect recombinant human (rhFGF20) on protecting cerebral blood vessels...