A5029685568- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Bioenergy crop production and management
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Plant Genetic and Mutation Studies
- Domain Adaptation and Few-Shot Learning
- Lung Cancer Research Studies
- Tissue Engineering and Regenerative Medicine
- GABA and Rice Research
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Blood groups and transfusion
- TGF-β signaling in diseases
- Microtubule and mitosis dynamics
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Neonatal Health and Biochemistry
- Protein Kinase Regulation and GTPase Signaling
- RNA Research and Splicing
- Neonatal and fetal brain pathology
- Advanced Neural Network Applications
- Seed Germination and Physiology
- Kruppel-like factors research
Chinese Academy of Sciences
2024-2025
Suzhou Institute of Biomedical Engineering and Technology
2024-2025
Shandong First Medical University
2022-2025
Jinan Central Hospital
2022-2025
West China Medical Center of Sichuan University
2014
Bethune International Peace Hospital
2014
Sichuan University
2009-2010
University of Cincinnati
2009
Pneumocystis jirovecii pneumonia (PJP), an opportunistic infection, is commonly observed in immunocompromised individuals, particularly those with cancer, and known for its significant morbidity mortality rates. Pralsetinib a highly specific inhibitor that targets advanced or metastatic non-small cell lung cancer (NSCLC) characterized by RET-fusion positivity. The incidence of PJP infection patients receiving pralsetinib was found to be infrequent. However, there currently lack consensus...
Abstract RhoA, a member of the Rho GTPase family, has been extensively studied in regulation cytoskeletal dynamics, gene transcription, cell cycle progression, and transformation. Overexpression RhoA is found many malignancies elevated activity associated with proliferation phenotypes cancer cells. We reported previously that was hyperactivated gastric tissues suppression could partially reverse phenotype cells, but underlying mechanism yet to be elucidated. It activation crucial for G1-S...
To explore glymphatic impairment in pediatric refractory epilepsy (RE) using multi-parameter magnetic resonance imaging (MRI), assess its relationship with white-matter (WM) abnormalities and clinical indicators, preliminarily evaluate the performance of MRI discriminating RE from drug-sensitive (DSE). We retrospectively included 70 patients DSE (mean age, 9.7 ± 3.5 years; male:female, 37:33) 26 (9.0 2.9 12:14). The diffusion tensor analysis along perivascular space (DTI-ALPS) index as well...
Previous studies have shown that RhoE, an atypical member of the Rho GTPase family, may play opposite role to RhoA in regulating cell proliferation and invasion. To explore relationship between RhoE malignant phenotypes human cancer, we determined expression patterns varying grade cancer tissues tested effects several underexpressing lines. Systemic immunocytochemistry analyses gastric, colorectal, lung breast carcinomas, respectively, showed protein was significantly decreased most cases...
Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological material. However, limited studies have been conducted with hUCMSCs compared BMMSCs. The present study was evaluate the effects in esophageal carcinoma (EC).hUCMSCs together EC were transplanted subcutaneously into BALB/c nude mice observe on tumor establishment. injected through caudal...
This study investigates the differences in brain functional activity and connectivity patterns between Cancer Pain (CP) patients Healthy Controls (HCs) using resting-state magnetic resonance imaging (rs-fMRI) to identify potential neuroimaging biomarkers.
Rho family is closely related with the growth , differentiation and metastasis of tumer cells. The objective this work to investigate expression RhoE in lung breast carcinoma their corresponding adjacent tissues, as well its relationship between clinical pathological grades. results study provide evidences for exploring biological functions significance RhoE.The was detected by immunohistochemistry 62 samples 34 samples, tissues were taken control.RhoE generally expressed normal but level...
Brain tissue segmentation plays a critical role in the diagnosis, treatment, and study of brain diseases. Accurately identifying these boundaries is essential for improving accuracy. However, distinguishing between different tissues can be challenging, as they often overlap. Existing deep learning methods primarily calculate overall results without adequately addressing local regions, leading to error propagation mis-segmentation along boundaries. In this study, we propose novel...
Objective To investigate the transcriptional activity of P53 in gastric cancer. Methods The p53 cancer was investigatedby dual-luciferase reporter assay. coding sequence amplified by reverse transcription-polymerase chain reaction(RT-PCR) and sequenced. expression P21WAF1/Cip1, Gadd45α Mdm2 detected immunohistochemistry 76 samples carcinoma, their adjacent tissues were analyzed as control. Results Thep53 higher human normal cell lines than that Furthermore, lowest MKN28 cells which mutated....