A5100680095- Dermatology and Skin Diseases
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Melanoma and MAPK Pathways
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- interferon and immune responses
- Hair Growth and Disorders
- Skin Protection and Aging
- Liver Diseases and Immunity
- RNA regulation and disease
- T-cell and B-cell Immunology
- Complement system in diseases
- PARP inhibition in cancer therapy
- Advancements in Transdermal Drug Delivery
- Genomics, phytochemicals, and oxidative stress
- Ectopic Pregnancy Diagnosis and Management
- Pharmacological Effects of Natural Compounds
- Cutaneous Melanoma Detection and Management
Hubei Academy of Agricultural Sciences
2023-2025
Ningbo University
2025
Dali University
2023-2024
Affiliated Hospital of Guizhou Medical University
2024
Guiyang Medical University
2024
Ministry of Agriculture and Rural Affairs
2023
China Agricultural University
2023
Beijing Center for Disease Prevention and Control
2010-2023
Penn State Milton S. Hershey Medical Center
2016-2023
Animal Science Research Institute
2023
Abstract An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2 pathogenesis lethality, but the mechanism remains unclear. In this study, N proteins of were found bind MASP-2, key serine protease in lectin pathway complement activation, resulting aberrant activation aggravated inflammatory lung injury. Either blocking protein:MASP-2 interaction or suppressing can significantly alleviate protein-induced hyper-activation injury vitro vivo . Complement was also observed...
Abstract Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses, but underlying mechanism remains unclear. In this study, N proteins including severe acute respiratory syndrome coronavirus (SARS-CoV), middle east (MERS-CoV) 2 (SARS-CoV-2), were found bind MASP-2, a key serine protease in lectin pathway complement activation, resulting excessive activation by potentiating MBL-dependent MASP-2 deposition C4b, activated C3 C5b-9....
In this study, by in vitro assay and live SARS-CoV-2 virus infection, we provide solid evidence that the NP associates with G3BP1 G3BP2 vivo . could efficiently suppress G3BP-mediated SG formation potentiate viral infection overcoming antiviral innate immunity mediated A549 cell lines conditional knockout mice ( g3bp1 -cKO) mice, which in-depth showing mechanism underlying NP-related pathogenesis through G3BPs.
After the first monovalent 2009 pandemic influenza A (H1N1) vaccine became available in September 2009, Chinese officials conducted a mass vaccination program Beijing. We evaluated safety and effectiveness of vaccine.
The mechanisms of action low-energy electrons (LEEs) generated in large quantities by ionizing radiation constitute an essential element our understanding early events radiolysis and radiobiology. We present the 2–20 eV electron energy dependence yields base damage (BD), BD-related cross-links (CLs), non-double-strand break (NDSB) clustered induced DNA. These new yield functions are impact LEEs on plasmid DNA films. is analyzed gel electrophoresis with without enzyme treatment. Maxima at 5...
This study aimed to evaluate the public health countermeasures against coronavirus disease 2019 (COVID-19) that are important for organizing mass gathering events (MGEs) during a pandemic and identify practices suitable application at future MGEs. analyzed data from Beijing 2022 Olympic Winter Games. The aforementioned analysis was conducted viewpoints of overseas stakeholders Chinese residents. comprehensive set established prevent transmission COVID-19 comprised bubble strategy,...
<title>Abstract</title> The destruction of the respiratory barrier caused by <italic>Mesomycoplasma hyopneumoniae</italic> plays a pivotal role in facilitating secondary infections other pathogens. However, pathogenesis <italic>M. breaching to establish infection remains largely elusive. In this study, Mhp390 encoded invasion tract barrier, including extracellular matrix and tracheal epithelial cells, were investigated through Transwell assay. Our finding indicated that may exploit host...
The important pathophysiological role of immune dysfunction, especially innate dysfunction in patients with acute-on-chronic liver failure (ACLF), has been investigated recent years, but dysregulation adaptive immunity remains poorly elucidated. aim this study was to (i) determine the CD3(+) T-lymphocyte count and balance between CD4(+) regulatory T (Tregs) conventional cells (Tconv) hepatitis B virus (HBV)-related ACLF patients; (ii) analyse frequencies Tregs subpopulations; (iii) assess...
Bifidobacterium as probiotics, play important roles in skin status, while the potential mechanisms interaction remains unknown. The study further explored mechanism of B. longum 68S ameliorating barrier damage from perspective gut-skin axis aging mice.B. supplied natural mouse model and fecal microbiota transplantation (FMT) experiment proves key role intestinal up-regulating production ceramide synthesis enzyme (SPT1) level improving damage. Moreover, SPT1 gene deletion to investigate on...
Background: Cryptococcal meningitis (CM) is a relatively common opportunistic infection in patients with human immunodeficiency virus (HIV) and can also occur no underlying disease. The aim of this study was to evaluate the clinical manifestations, laboratory findings, diagnosis misdiagnosis, treatment, prognosis CM at tertiary care hospital. Methods: We performed retrospective 55 hospital from January 1, 1992 December 31, 2013. All had definite based on etiology. Results: positive...
Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (EP), leading to a mild and chronic in swine. Relative control has been attained through active vaccination programs, but remains significant economic challenge swine industry. Cellular immunity plays key role prevention pneumonia. Therefore, development more efficient vaccine that confers strong against M. necessary. In this study, multi-antigen chimera (L9m6) was constructed by combining heat-labile enterotoxin...
The treatment of myasthenia gravis (MG) has advanced from steroids and traditional immunosuppressants to targeted immunotherapy. Targeted immunotherapy been successfully employed in clinical practice recent years. This study aimed explore the emerging trend MG summarize knowledge structure through bibliometric methods.The Web Science Core Collection database (WoSCC) was chosen retrieve literature on for MG. Two analysis software, VOSviewer CiteSpace, online platform were mainly used evaluate...
Objective. To explore cortical reorganization of patients recovered from Bell’s palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements provide more evidence for acupuncture clinical treatment BP. Methods. We collected 17 BP with complete recovery (BP group) 20 healthy volunteers (control accepted the fMRI scans lip pursing movements, respectively. Results. It was found that there were significant differences brain status between two...
Objectives: To investigate whether the fecal microbiome of Parkinson's disease patients differs from that healthy population and explore pathogenesis new treatment idiopathic disease. Methods: A total 30 diagnosed as Parkinson (PD group) in Beijing Friendship Hospital between April 2017 June 2018 were enrolled controls (NC recruited at same time.Medical records score unified rating scale (UPDRS) collected fresh samples obtained stored refrigerator (-80℃). The microbial compositions...
The aim of this study was to analyze and compare procalcitonin (PCT) levels in serum cerebrospinal fluid (CSF) as tools for detecting bacterial meningitis (BM) children. Serum CSF PCT well albumin index (AI = albumin/serum × 1000) were measured from 29 BM, 25 viral (VM), 47 non-meningitis patients. Differences between groups only significant. A stronger positive correlation level AI observed the BM patients ( R 0.68, P < .001). As a predictor area under receiver operating characteristics...
BACKGROUND Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are two common clinical autoimmune liver diseases, some patients have both diseases; this feature is called AIH-PBC overlap syndrome. thyroid disease (AITD) the most frequently overlapping extrahepatic disease. Immunoglobulin (IgG) 4-related an recognized in recent years, characterized by elevated serum IgG4 levels infiltration of IgG4-positive plasma cells tissues. CASE SUMMARY A 68-year-old female patient was...