A5078316274- Toxoplasma gondii Research Studies
- Invertebrate Immune Response Mechanisms
- Pregnancy and preeclampsia studies
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Aquaculture disease management and microbiota
- Malaria Research and Control
- Mosquito-borne diseases and control
- Rabies epidemiology and control
- Autophagy in Disease and Therapy
University of Cambridge
2020-2024
The apical complex is the instrument of invasion used by apicomplexan parasites, and conoid a conspicuous feature this apparatus found throughout phylum. conoid, however, believed to be heavily reduced or missing from Plasmodium species other members class Aconoidasida. Relatively few proteins have previously been identified, making it difficult address how conserved phylum, whether genuinely some major groups. Moreover, parasites such as cycle through 3 invasive forms, there possibility...
The placenta is a selective maternal-fetal barrier that provides nourishment and protection from infections. However, certain pathogens can attach to even cross the placenta, causing pregnancy complications with potential lifelong impacts on child's health. Here, we profiled at single-cell level placental responses three associated intrauterine complications—Plasmodium falciparum, Listeria monocytogenes, Toxoplasma gondii. We found upon exposure pathogens, all lineages trigger inflammatory...
Apicomplexans are ubiquitous intracellular parasites of animals. These use a programmed sequence secretory events to find, invade, and then re-engineer their host cells enable parasite growth proliferation. The organelles micronemes rhoptries mediate the first steps invasion. Both secrete contents through apical complex which provides an opening in parasite's elaborate inner membrane (IMC) - extensive subpellicular system flattened cisternae proteinaceous meshwork that otherwise limits...
Abstract The apical complex is the instrument of invasion used by apicomplexan parasites, and conoid a conspicuous feature this apparatus found throughout phylum. conoid, however, believed to be heavily reduced or missing from Plasmodium species other members class Aconoidasida. Relatively few proteins have previously been identified, making it difficult address how conserved phylum, whether genuinely some major groups. Moreover, parasites such as cycle through three invasive forms there...
ABSTRACT Toxoplasma gondii is a protozoan parasite in the apicomplexan phylum. Apicomplexan parasites replicate using variety of non-canonical cell division modes, distinct from binary fission, whose molecular regulation incompletely understood. T. replicates by endodyogeny its intermediate hosts, and schizogony definitive host. To improve our understanding how these unusual, flexible modes are regulated, we characterised homologues cell-cycle checkpoint kinases ATM ATR. These...
ABSTRACT Apicomplexans are ubiquitous intracellular parasites of animals. These use a programmed sequence secretory events to find, invade, and then reengineer their host cells enable parasite growth proliferation. The organelles micronemes rhoptries mediate the first steps invasion. Both secrete contents through apical complex which provides an opening in parasite’s elaborate inner membrane (IMC) — extensive subpellicular system flattened cisternae proteinaceous meshwork that otherwise...
Abstract Placental infections are a major worldwide burden, particularly in developing countries. The placenta is transient tissue located at the interface between mother and fetus. Some pathogens can access placental barrier resulting pathological transmission from to fetus, which may have profound impact on health of Limited accessibility, critical differences humans mice, and, until recently, lack proper vitro models, hampered our understanding early response pathogens. Here we use...