A5026281324- Pancreatitis Pathology and Treatment
- Research on Leishmaniasis Studies
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Trypanosoma species research and implications
Paul Ehrlich Institut
2023
University Medical Center of the Johannes Gutenberg University Mainz
2023
Johannes Gutenberg University Mainz
2023
The virulence of intracellular pathogens relies largely on the ability to survive and replicate within phagocytes, but also release transfer into new host cells. Such cell-to-cell could represent a target for counteracting microbial pathogenesis. However, our understanding underlying cellular molecular processes remains woefully insufficient. Using intravital 2-photon microscopy caspase-3 activation in Leishmania major (L. major)-infected live skin, we show increased apoptosis cells infected...
Leishmania is the causative agent of tropical neglected disease leishmaniasis and infects macrophages as its definitive host cell. In order to sustain propagate infections, parasites have complete cycles exit re-infection. Yet, mechanism driving parasite spread other cells remains unclear. Recent studies reported pro-inflammatory monocytes replicative niche major showed prolonged expression IL-1β at site infection, indicating an activation NLRP3 inflammasome pointing toward pyroptosis a...
Leishmania is the causative agent of tropical neglected disease leishmaniasis and infects macrophages as its definitive host cell . In order to sustain propagate infections, parasites have complete cycles exit re-infection. Yet, mechanism driving parasite spread other cells remains unclear. Recent studies reported pro-inflammatory monocytes replicative niche L. major showed prolonged expression IL-1β at site infection, indicating an activation NLRP3 inflammasome pointing towards pyroptosis a...